Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Fatigue
ADR ID BADD_A01626
ADR Hierarchy
08      General disorders and administration site conditions
08.01      General system disorders NEC
08.01.01      Asthenic conditions
08.01.01.002      Fatigue
Description A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. [CTCAE] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. [MeSH]
MedDRA Code 10016256
MeSH ID D005221; D005221; D005221
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Enervation | Exhaustion | Exhaustion due to excessive exertion | Exhaustion due to exposure | Fatigability | Fatigability generalized | Fatigability lumbar | Fatigability of knees | Fatigue | Fatigue extreme | Fatiguability | Lassitude | Loss physical strength | Prostration | TATT | Tired all the time | Tired and heavy | Tired out | Tiredness | Washed-out | Weariness | Worn out | Fatigue aggravated | Depressive weariness | Fatigueability generalised | Chronic fatigue | Fatiguability generalised
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Epidermal growth factor receptorP00533T59328
Receptor tyrosine-protein kinase erbB-2P04626T14597
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D000032-phenylbutyric acid--
BADD_D000054-oxo-3-(3-oxo-1-phenylbutyl)chromen-2-olate--
BADD_D000064r,6r-dorzolamide--
BADD_D00008Abacavir--
BADD_D00009Abacavir succinate--
BADD_D00010Abacavir sulfate--
BADD_D00011Abarelix--
BADD_D00014Abiraterone--
BADD_D00015Abiraterone acetate--
BADD_D00019Acebutolol--
BADD_D00020Acebutolol hydrochloride--
BADD_D00023Acetaminophen--
BADD_D00025Acetazolamide--
BADD_D00028Acetohydroxamic acid--
BADD_D00029Acetyl sulfisoxazole--
BADD_D00036Acitretin--
BADD_D00039Acyclovir--
BADD_D00040Acyclovir sodium--
BADD_D00044Adefovir dipivoxil--
BADD_D00046Ado-trastuzumab emtansine--
BADD_D00047Afatinib--
BADD_D00048Aflibercept--
BADD_D00049Agalsidase beta--
BADD_D00050Agomelatine--
BADD_D00052Albendazole--
BADD_D00055Albumin microspheres (human)--
BADD_D00056Albuterol--
BADD_D00058Alcaftadine--
BADD_D00063Alectinib hydrochloride--
BADD_D00064Alemtuzumab--
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