Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alfuzosin
Drug ID BADD_D00069
Description Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70.[A228483] Alfuzosin is an alpha-1 adrenergic blocker used in the symptomatic treatment of BPH that works by relaxing the muscles in the prostate and bladder neck.[L31593] It was initially approved by the FDA in 2003 and is marketed by several pharmaceutical companies.[L9251]
Indications and Usage For the reduction of urinary obstruction and relief of associated manifestations (eg. sensation of incomplete bladder emptying or straining, urgency, interrupted or weak stream) in patients with symptomatic beningn prostatic hyperplasia.
Marketing Status Prescription; Discontinued
ATC Code G04CA01
DrugBank ID DB00346
KEGG ID D07124
MeSH ID C047638
PubChem ID 2092
NDC Product Code Not Available
Synonyms alfuzosin | alphuzosine | N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide | alfusozine | alfuzosin hydrochloride | UroXatral | Benestan | Urion | Xatral | Alfetim
Chemical Information
Molecular Formula C19H27N5O4
CAS Registry Number 81403-80-7
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Angina pectoris02.02.02.002;
Angioedema23.04.01.001; Available
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Blood pressure diastolic decreased13.14.03.003--Not Available
Blood pressure fluctuation24.06.01.002--Not Available
Blood pressure systolic decreased13.14.03.007--Not Available
Bursitis15.04.01.001--Not Available
Cardiovascular disorder02.01.01.001; Available
Chest pain22.02.08.003;; Available
Cholestasis09.01.01.001--Not Available
Coronary artery disease24.04.04.006; Available
Dermatitis23.03.04.002--Not Available
Discomfort08.01.08.003--Not Available
Dry mouth07.06.01.002--
Ear disorder04.03.01.001--Not Available
Eye disorder06.08.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
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