Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name 4-oxo-3-(3-oxo-1-phenylbutyl)chromen-2-olate
Drug ID BADD_D00005
Description Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Indications and Usage For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.
Marketing Status Discontinued; Prescription
ATC Code B01AA03
DrugBank ID DB00682
KEGG ID D00564
MeSH ID D014859
PubChem ID 23690541
TTD Drug ID D0E3OF
NDC Product Code 76282-329; 51407-348; 65162-769; 70934-587; 70934-911; 71610-448; 76282-334; 43353-030; 50090-3263; 51407-345; 51407-346; 65162-761; 65162-767; 70518-2395; 71610-462; 76282-335; 43353-029; 50090-2582; 50090-2586; 50090-5058; 70934-821; 76282-328; 43353-023; 50090-2617; 70518-2381; 70518-2382; 76282-333; 43353-028; 43353-054; 51407-341; 51407-343; 65162-766; 76282-330; 76282-331; 70518-2380; 71335-1824; 50090-2645; 51407-344; 51407-349; 65162-763; 70934-820; 71610-490; 76282-332; 50090-2654; 50090-2936; 51407-342; 65162-762; 65162-764; 70518-2383; 70518-2816; 76282-327; 43353-033; 51407-347; 70518-2394; 70518-2717; 71335-1595; 71335-1786; 71610-491; 43353-021; 43353-053; 50090-2613; 50090-2646; 65162-765; 65162-768; 71610-458; 71610-519
Synonyms Warfarin | 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one | Apo-Warfarin | Aldocumar | Gen-Warfarin | Warfant | Coumadin | Marevan | Warfarin Potassium | Potassium, Warfarin | Warfarin Sodium | Sodium, Warfarin | Coumadine | Tedicumar
Chemical Information
Molecular Formula C19H15LiO4
CAS Registry Number 81-81-2
SMILES [Li+].CC(=O)CC(C1=CC=CC=C1)C2=C(OC3=CC=CC=C3C2=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Coagulation time shortenedCytochrome P450 2C19P33261Not AvailableNot Available
HaemorrhageCytochrome P450 2C9P11712T19244Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Asthenia08.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Coma17.02.09.001--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis01.01.03.001; 24.07.06.002; 23.06.01.001--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Fat embolism24.01.01.012; 12.01.08.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematuria20.02.01.006; 24.07.01.047--
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