Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetyl sulfisoxazole
Drug ID BADD_D00029
Description Sulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, _dihydropteroate synthase_, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [L2788]. It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [L2790].
Indications and Usage For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Marketing Status Not Available
ATC Code Not Available
DrugBank ID DB14033
KEGG ID Not Available
MeSH ID C005387
PubChem ID 6662
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms acetyl sulfisoxazole
Chemical Information
Molecular Formula C13H15N3O4S
CAS Registry Number 80-74-0
SMILES CC1=C(ON=C1C)N(C(=O)C)S(=O)(=O)C2=CC=C(C=C2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Allergic myocarditis10.01.03.039; 02.04.03.003--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anuria20.01.03.002--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arteritis24.05.01.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Chills15.05.03.016; 08.01.09.001--
Cough22.02.03.001--
Crystalluria20.02.01.003--Not Available
Cyanosis22.02.02.007; 02.01.02.002; 24.03.01.007--
Deafness04.02.01.001--Not Available
Depression19.15.01.001--
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea02.01.03.002; 22.02.01.004--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
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