Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alemtuzumab
Drug ID BADD_D00064
Description Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.
Indications and Usage Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia.
Marketing Status Prescription
ATC Code L04AA34
DrugBank ID DB00087
KEGG ID D02802
MeSH ID D000074323
PubChem ID Not Available
TTD Drug ID D01ZYG
NDC Product Code 58468-0200; 58468-0357
Synonyms Alemtuzumab | Campath 1H | Monoclonal Antibody Campath-1H | Antibody Campath-1H, Monoclonal | Campath-1H, Monoclonal Antibody | Monoclonal Antibody Campath 1H | Campath-1H | Campath1H | Campath 1M | Campath-1M | MabCambath | Lemtrada | Campath 1G | Campath-1-G | Campath 1 G | Campath1G | Campath-1G | Campath
Chemical Information
Molecular Formula Not Available
CAS Registry Number 216503-57-0
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abscess bacterial11.02.01.027--Not Available
Acute respiratory distress syndrome22.01.03.001--
Anaemia01.03.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrial tachycardia02.03.03.004--
Back pain15.03.04.005--
Basedow's disease10.04.08.004; 06.09.04.003; 05.02.02.003--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Cardiac failure acute02.05.01.005--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiomyopathy02.04.01.001--Not Available
CD8 lymphocytes increased13.01.06.044--Not Available
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.001--Not Available
Chills15.05.03.016; 08.01.09.001--
Cough22.02.03.001--
Cytomegalovirus infection11.05.01.002--
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dysaesthesia17.02.06.003--
Dysfunctional uterine bleeding21.01.01.001; 05.05.01.003--Not Available
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