Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abacavir succinate
Drug ID BADD_D00009
Description Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Indications and Usage For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Marketing Status Prescription
ATC Code J05AF06
DrugBank ID DB01048
KEGG ID D02734
MeSH ID C106538
PubChem ID 9822500
TTD Drug ID D0A4IJ
NDC Product Code 31722-562; 50268-049; 70518-1274; 55111-920; 31722-557; 72865-167; 65862-073; 0121-0897; 64380-717; 69097-514; 0904-6874
Synonyms abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate
Chemical Information
Molecular Formula C18H24N6O5
CAS Registry Number 168146-84-7
SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.C(CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityHLA class I histocompatibility antigen, B alpha chainP01889Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Acute respiratory distress syndrome22.01.03.001--
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Blood creatinine increased13.13.01.004--
Body temperature increased13.15.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Chills15.05.03.016; 08.01.09.001--
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug hypersensitivity10.01.01.001--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gamma-glutamyltransferase increased13.03.01.011--
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
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