Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetazolamide
Drug ID BADD_D00025
Description One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Indications and Usage For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
Marketing Status approved; vet_approved
ATC Code S01EC01
DrugBank ID DB00819
KEGG ID D00218
MeSH ID D000086
PubChem ID 1986
TTD Drug ID D0E1SW
NDC Product Code 72578-150; 72888-048; 12658-0475; 12658-0591; 23155-313; 50090-5945; 68382-076; 72888-047; 12658-0557; 10135-773; 23155-287; 23155-831; 29033-030; 0143-9503; 51672-4022; 62135-607; 62332-349; 70771-1827; 70954-034; 71205-308; 72578-149; 12658-0453; 12658-0457; 10135-772; 39822-0190; 46708-349; 52817-200; 52817-201; 63629-1194; 63629-1195; 70771-1828; 70954-033; 71335-9729; 71930-009; 72789-045; 12658-0460; 50090-5617; 70771-1490; 12658-0359; 12658-0465; 12658-0468; 12658-0471; 12658-0556; 12658-0592; 51927-2276; 23155-288; 23155-787; 50090-5217; 60687-578; 62135-612; 69367-209; 70710-1591; 72789-237; 0904-6663; 12658-0438; 12658-0466; 16729-331; 50268-054; 64380-833; 64380-834; 70756-720; 14593-801; 49452-0018; 51927-0266; 42291-090; 70756-721; 72789-238; 12658-0474; 42419-008; 0143-9006; 51672-4023; 60687-619; 65841-762; 12817-363; 50090-4511; 50742-233; 62135-608; 71930-008; 12658-0481; 12658-0593; 38779-0410; 62991-2517; 67123-001; 42291-089; 51655-331; 55289-720
UNII O3FX965V0I
Synonyms Acetazolamide | Acetazolam | Acetazolamide Sodium, (Sterile) | Acetazolamide, Monosodium Salt | Ak-Zol | Ak Zol | AkZol | Apo-Acetazolamide | Apo Acetazolamide | ApoAcetazolamide | Diacarb | Diamox | Diuramide | Défiltran | Edemox | Glauconox | Glaupax | Huma-Zolamide | Huma Zolamide | HumaZolamide | Acetadiazol
Chemical Information
Molecular Formula C4H6N4O3S2
CAS Registry Number 59-66-5
SMILES CC(=O)NC1=NN=C(S1)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001---
Anaphylactic shock24.06.02.004; 10.01.07.002---
Anaphylactoid reaction24.06.03.007; 10.01.07.003---
Aplastic anaemia01.03.03.002---
Asthenia08.01.01.001---
Ataxia17.02.02.001; 08.01.02.004--
Body temperature increased13.15.01.001---
Cardiac arrest02.03.04.001--
Chills15.05.03.016; 08.01.09.001--
Condition aggravated08.01.03.004---
Confusional state19.13.01.001; 17.02.03.005--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002---
Discomfort08.01.08.003---
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrolyte imbalance14.05.01.002---
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye inflammation06.04.05.002---
Eye pain06.08.03.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.016--
Gastrointestinal disorder07.11.01.001---
Glycosuria20.02.01.005--
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ADReCS-Target
Drug Name ADR Term Target
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