Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetazolamide
Drug ID BADD_D00025
Description One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Indications and Usage For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
Marketing Status approved; vet_approved
ATC Code S01EC01
DrugBank ID DB00819
KEGG ID D00218
MeSH ID D000086
PubChem ID 1986
TTD Drug ID D0E1SW
NDC Product Code 72578-150; 72888-048; 12658-0475; 12658-0591; 23155-313; 50090-5945; 68382-076; 72888-047; 12658-0557; 10135-773; 23155-287; 23155-831; 29033-030; 0143-9503; 51672-4022; 62135-607; 62332-349; 70771-1827; 70954-034; 71205-308; 72578-149; 12658-0453; 12658-0457; 10135-772; 39822-0190; 46708-349; 52817-200; 52817-201; 63629-1194; 63629-1195; 70771-1828; 70954-033; 71335-9729; 71930-009; 72789-045; 12658-0460; 50090-5617; 70771-1490; 12658-0359; 12658-0465; 12658-0468; 12658-0471; 12658-0556; 12658-0592; 51927-2276; 23155-288; 23155-787; 50090-5217; 60687-578; 62135-612; 69367-209; 70710-1591; 72789-237; 0904-6663; 12658-0438; 12658-0466; 16729-331; 50268-054; 64380-833; 64380-834; 70756-720; 14593-801; 49452-0018; 51927-0266; 42291-090; 70756-721; 72789-238; 12658-0474; 42419-008; 0143-9006; 51672-4023; 60687-619; 65841-762; 12817-363; 50090-4511; 50742-233; 62135-608; 71930-008; 12658-0481; 12658-0593; 38779-0410; 62991-2517; 67123-001; 42291-089; 51655-331; 55289-720
UNII O3FX965V0I
Synonyms Acetazolamide | Acetazolam | Acetazolamide Sodium, (Sterile) | Acetazolamide, Monosodium Salt | Ak-Zol | Ak Zol | AkZol | Apo-Acetazolamide | Apo Acetazolamide | ApoAcetazolamide | Diacarb | Diamox | Diuramide | Défiltran | Edemox | Glauconox | Glaupax | Huma-Zolamide | Huma Zolamide | HumaZolamide | Acetadiazol
Chemical Information
Molecular Formula C4H6N4O3S2
CAS Registry Number 59-66-5
SMILES CC(=O)NC1=NN=C(S1)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Aplastic anaemia01.03.03.002--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Body temperature increased13.15.01.001--Not Available
Cardiac arrest02.03.04.001--
Chills15.05.03.016; 08.01.09.001--
Condition aggravated08.01.03.004--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.11.05.003--
Electrolyte imbalance14.05.01.002--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye inflammation06.04.05.002--Not Available
Eye pain06.08.03.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.002--
Gastrointestinal disorder07.11.01.001--Not Available
Glycosuria20.02.01.005--
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ADReCS-Target
Drug Name ADR Term Target
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