Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abiraterone acetate
Drug ID BADD_D00015
Description Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Indications and Usage Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
Marketing Status Prescription
ATC Code L02BX03
DrugBank ID DB05812
KEGG ID D09701
MeSH ID D000069501
PubChem ID 9821849
TTD Drug ID D06CNP
NDC Product Code 43598-358; 64980-418; 51407-181; 65089-0051; 16714-963; 72603-110; 57894-150; 12578-619; 62068-380; 68554-0082; 76302-016; 64918-1405; 69988-0011; 16812-004; 17337-0051; 72606-573; 0143-9597; 22552-0035; 72205-030; 60505-4327; 64679-021; 47621-043; 72789-213; 54893-0019; 69539-049; 68001-489; 0904-6948; 60505-4764; 26251-0004; 77382-0040; 65129-1323; 63190-0570; 0378-6920; 63592-4520; 82293-001; 62756-199; 77382-0120; 0093-1125; 0378-6921; 53069-1030; 57894-195; 59057-000; 59057-006; 17337-0056; 68462-135; 72606-566; 53183-4040; 47335-401; 82293-002; 64918-1403
Synonyms Abiraterone Acetate | 17-(3-pyridyl)-5,16-androstadien-3beta-acetate | Zytiga | CB 7630 | CB-7630 | CB7630
Chemical Information
Molecular Formula C26H33NO2
CAS Registry Number 154229-18-2
SMILES CC(=O)OC1CCC2(C3CCC4(C(C3CC=C2C1)CC=C4C5=CN=CC=C5)C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Arrhythmia02.03.02.001--Not Available
Aspartate aminotransferase increased13.03.01.006--
Blood bilirubin increased13.03.01.008--
Cardiac failure02.05.01.001--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Fall12.01.08.002--
Fatigue08.01.01.002--
Fracture12.04.02.001; 15.08.02.001--
Groin pain15.03.02.004--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypernatraemia14.05.04.001--
Hypertension24.08.02.001--
Hypertriglyceridaemia14.08.02.001--
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.001--
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Joint swelling15.01.02.004--Not Available
Lymphopenia01.02.02.002--Not Available
Myopathy15.05.05.001--Not Available
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