Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abarelix
Drug ID BADD_D00011
Description Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.
Indications and Usage For palliative treatment of advanced prostate cancer.
Marketing Status Discontinued
ATC Code L02BX01
DrugBank ID DB00106
KEGG ID D02738
MeSH ID C423508
PubChem ID 16131215
TTD Drug ID D01AHO
NDC Product Code Not Available
Synonyms abarelix | Plenaxis | PPI-149
Chemical Information
Molecular Formula C72H95ClN14O14
CAS Registry Number 183552-38-7
SMILES CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)C( CC2=CC=C(C=C2)O)N(C)C(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(= O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood triglycerides increased13.12.03.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast pain21.05.05.003--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysuria20.02.02.002--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Menopausal symptoms21.02.02.002--Not Available
Nausea07.01.07.001--
Nipple pain21.05.05.009--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Pain08.01.08.004--
Pollakiuria20.02.02.007--
Sleep disorder19.02.04.001--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary retention20.02.02.011--
Urinary tract infection11.01.14.004; 20.08.02.001--
Hot flush21.02.02.001; 24.03.01.005; 08.01.03.027--
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