Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acyclovir sodium
Drug ID BADD_D00040
Description Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.[L7321] Acyclovir was granted FDA approval on 29 March 1982.[L7318]
Indications and Usage An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older.[L7303] Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox.[L7315] An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients.[L7318] An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older.[L7321] An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis.[L7324] An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.[L7327]
Marketing Status approved
ATC Code S01AD03; J05AB01; D06BB03
DrugBank ID DB00787
KEGG ID D02764
MeSH ID D000212
PubChem ID 23665721
TTD Drug ID D0B5MP
NDC Product Code 63323-325; 14335-150; 55150-154; 55150-155; 46014-1019
UNII 927L42J563
Synonyms Acyclovir | 9-((2-Hydroxyethoxy)methyl)guanine | Aciclovir | Acycloguanosine | Herpoviric | Aciclobeta | Aciclostad | Isavir | Laciken | Mapox | Maynar | Milavir | Opthavir | Supraviran | Viclovir | Vipral | Virax-Puren | Virax Puren | ViraxPuren | Virherpes | Virmen | Virolex | Virupos | Virzin | Wellcome-248U | Wellcome 248U | Wellcome248U | Zoliparin | Zovirax | Zyclir | Aciclovir Alonga | Alonga, Aciclovir | Acifur | Acipen Solutab | Solutab, Acipen | Acivir | Activir | Acyclo-V | Acyclo V | Acyclovir Sodium | Sodium, Acyclovir | Antiherpes Creme | aciclovir von ct | Avirax | Cicloferon | Clonorax | Cusiviral | Genvir | Herpetad | Herpofug | Herpotern | Aci-Sanorania | Aci Sanorania | Aciclovir-Sanorania | Aciclovir Sanorania | Acic
Chemical Information
Molecular Formula C8H10N5NaO3
CAS Registry Number 69657-51-8
SMILES C1=NC2=C(N1COCCO)N=C(N=C2[O-])N.[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blood creatinine increased13.13.01.004--
Blood urea13.13.01.019--Not Available
Blood urea increased13.13.01.006--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Delirium19.13.02.001--
Depressed level of consciousness17.02.04.002--
Diarrhoea07.02.01.001--
Disseminated intravascular coagulation24.01.01.010; 01.01.02.002--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dysaesthesia23.03.03.077; 17.02.06.003--
Encephalopathy17.13.02.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Haemolysis01.06.04.002--
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hypersensitivity vasculitis10.02.02.017; 01.01.04.008; 24.12.04.013; 23.06.02.005--Not Available
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