Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetaminophen
Drug ID BADD_D00023
Description Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO).[A176318] It is also used for its antipyretic effects, helping to reduce fever.[F4124] This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.[L5756,L5774,F4124,Label] Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products.[L5783] Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages.[L5783] Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.[L5786,L5789,Label]
Indications and Usage For temporary relief of fever, minor aches, and pains.
Marketing Status Prescription; OTC; Discontinued
ATC Code N02BE01
DrugBank ID DB00316
KEGG ID D00217
MeSH ID D000082
PubChem ID 1983
TTD Drug ID D0U5QK
NDC Product Code 47682-114; 68016-636; 69842-491; 68094-015; 63868-679; 70000-0310; 45802-201; 68071-4362; 58602-873; 63187-293; 72288-300; 58940-001; 68788-7359; 72036-100; 69842-764; 66326-204; 0615-8398; 68196-484; 70518-0444; 63941-282; 63868-591; 59779-754; 37012-288; 49580-0288; 0121-1314; 0363-9947; 0113-7000; 76281-327; 41250-244; 68210-2002; 69676-0058; 63941-401; 11673-618; 0406-4255; 56062-175; 50090-5313; 49035-531; 0904-6720; 0904-6719; 62011-0434; 71309-077; 0904-6536; 41250-227; 21130-111; 37808-704; 63941-288; 24201-100; 50090-5350; 21130-178; 72288-544; 70000-0137; 0406-6056; 51824-086; 51662-1540; 0113-5002; 62011-0339; 37808-945; 68391-288; 49035-777; 62011-0336; 11822-0519; 41250-246; 69842-707; 68001-495; 69842-297; 68016-029; 68016-333; 70677-0093; 36800-557; 0264-4100; 41250-590; 68998-092; 0615-8397; 69842-636; 50580-209; 70000-0472; 46122-170; 63029-610; 68094-587; 49483-697; 0363-0104; 73173-010; 70677-0018; 46122-552; 36800-770; 56062-130; 69842-793; 59779-946; 71335-0848; 69842-093; 70677-0131; 0904-6749; 55910-661; 68998-001; 56062-484; 50090-0395; 45865-656; 55670-122; 70677-0117; 47682-113; 49580-0685; 59644-9925; 11822-9440; 63981-700; 0615-8409; 53604-703; 55289-880; 71205-478; 0113-4010; 68210-1014; 50580-522; 63868-866; 37808-792; 68788-7709; 69848-003; 36800-369; 0121-0939; 17856-0202; 63187-588; 51672-2115; 50580-433; 57896-221; 54838-144; 30142-157; 62011-0023; 72189-120; 67091-311; 49483-341; 72207-114; 0363-9604; 62011-0238; 41163-514; 58602-745; 70677-0116; 0363-0132; 55315-082; 50580-521; 50580-487; 53604-601; 71399-8025; 0781-9274; 53943-201; 41250-278; 69842-750; 49035-975; 0363-0336; 72476-186; 11822-0107; 58602-220; 51552-0086; 49638-109; 68998-098; 69842-298; 69842-450; 0363-4501; 0113-1889; 63629-1516; 68210-1300; 56062-227; 51645-706; 55910-691; 0363-0971; 0615-8250; 63629-8240; 30142-792; 54738-548; 70729-001; 51013-182; 62011-0001; 62011-0183; 51824-087; 68196-544; 71335-0219; 55315-288; 49638-106; 68788-7743; 68016-243; 59556-854; 68210-4125; 47682-115; 69842-258; 50580-509; 49348-325; 41163-500; 69842-311; 70000-0305; 50090-2588; 61474-4265; 68998-300; 58103-115; 66689-055; 55910-282; 55670-468; 56062-946; 25000-901; 33992-0282; 69732-001; 47682-175; 49348-730; 36800-202; 67046-023; 41163-888; 55910-021; 36800-397; 50844-255; 71205-263; 70518-1855; 37808-747; 55910-010; 69842-322; 71309-001; 56062-161; 36800-414; 63187-968; 0113-7544; 0121-0966; 49314-1763; 54738-040; 29485-7003; 30142-591; 55319-494; 50844-751; 68210-4168; 51824-049; 36800-455; 42681-7076; 49580-0682; 59779-350; 41520-818; 69842-544; 0406-0422; 49999-131; 10202-701; 70120-023; 0135-0539; 61919-271; 69477-000; 0113-7130; 46122-630; 62011-0002; 68210-3100; 69676-0041; 72288-175; 41520-990; 50580-490; 10135-152; 76281-328; 68196-919; 60760-453; 62011-0460; 50580-579; 50580-600; 63029-620; 69842-073; 79903-032; 25000-071; 54859-809; 61245-145; 11673-966; 53604-701; 69842-390; 0781-3156; 50580-783; 46122-696; 50090-5469; 71335-0524; 0363-0959; 58103-124; 0485-0057; 0406-7845; 33992-0175; 63868-129; 70518-2798; 0363-9798; 69842-915; 72036-098; 23155-202; 41250-802; 69842-223; 72036-170; 47682-009; 11673-105; 67060-210; 50580-460; 49035-042; 72288-766; 58602-204; 69732-002; 55794-101; 72476-185; 69168-418; 66715-6708; 36800-900; 50580-692; 69842-780; 41250-650; 0113-0161; 11673-841; 0363-0531; 66715-6837
Synonyms Acetaminophen | Acetominophen | Hydroxyacetanilide | APAP | p-Acetamidophenol | p-Hydroxyacetanilide | Paracetamol | N-(4-Hydroxyphenyl)acetanilide | Acetamidophenol | N-Acetyl-p-aminophenol | Acephen | Acetaco | Tylenol | Anacin-3 | Anacin 3 | Anacin3 | Datril | Panadol | Acamol | Algotropyl
Chemical Information
Molecular Formula C8H9NO2
CAS Registry Number 103-90-2
SMILES CC(=O)NC1=CC=C(C=C1)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionPoly(A) polymerase alphaP25500Not Available2609350; 2603160; 3135633; 2213573; 2764988; 6484986; 4026879; 6339903; 3787633; 2242021; 3978756; 4038475
Cytogenetic abnormalityPoly(A) polymerase alphaP25500Not Available2609350; 2603160; 3135633; 2213573; 2764988; 6484986; 4026879; 6339903; 3787633; 2242021; 3978756; 4038475
HaemolysisHaptoglobinP00738T177108941205; 12013368; 10584588; 11007105; 16166048; 10584589; 8363113
HaemolysisGlucose-6-phosphate 1-dehydrogenaseP11413T634848941205; 12013368; 10584588; 11007105; 16166048; 10584589; 8363113
Hepatic necrosisSulfotransferase 1A3P0DMM9Not Available2882969; 3952741; 8378925
HepatotoxicityTumor necrosis factorP06804Not Available25884831
HepatotoxicityATP-binding cassette subfamily B member 1AQ9JK64Not Available25678313
HepatotoxicityAlpha-fetoproteinP02771T1082825894252
HepatotoxicityAlanine aminotransferase 1P24298Not Available3723405; 8728501; 3107095
HepatotoxicityCytochrome P450 3A4P08684T3784812376703; 12376675; 15764585; 15358766
HepatotoxicityCytochrome P450 2E1P05181Not Available12376703; 12376675; 15764585; 15358766; 3973835; 10741631
HepatotoxicityUDP-glucuronosyltransferase 2B15P54855Not Available16696573; 11854153; 15933229; 16187975
HepatotoxicityOrnithine decarboxylaseP11926T603663989355; 3624765; 3432943
HepatotoxicityAlkaline phosphatase, tissue-nonspecific isozymeP05186T095381626578; 15459622; 10632283
HepatotoxicitySolute carrier family 12 member 3P55017T848862446617; 6135422; 2538005
HepatotoxicityUDP-glucuronosyltransferase 1A1P22309T9348016696573; 11854153; 15933229; 16187975
HepatotoxicityTranscription factor JunP05412T690858827825; 6729816
HepatotoxicityCaspase recruitment domain-containing protein 10Q9BWT7Not Available12376703; 12376675; 15764585; 15358766
HepatotoxicityAlbuminP02768T6306825894252
HepatotoxicityTumor necrosis factorP06804Not Available25520918
HepatotoxicityCytochrome P450 1A2P05177Not Available12376703; 12376675; 15764585; 15358766; 25894252
HepatotoxicityTransforming protein v-Fos/v-FoxP29176Not Available8827825; 6729816
HepatotoxicityMyeloperoxidaseP11247Not Available25884831
HepatotoxicityCytochrome P450 2E1P05181Not Available8470644; 7508362; 10980926
HepatotoxicityUDP-glucuronosyltransferase 2B15P54855Not Available1872890; 1676648; 6284753
HepatotoxicityUDP-glucuronosyltransferase 1-6P19224Not Available16696573; 11854153; 15933229; 16187975
HepatotoxicityAspartate aminotransferase, mitochondrialP05202Not Available25884831
HepatotoxicityCytochrome P450 2E1Q05421Not Available25884831
HepatotoxicityUDP-glucuronosyltransferase 1A9O60656Not Available16696573; 11854153; 15933229; 16187975
HyperglycaemiaAlanine aminotransferase 2Q8BGT5Not Available6870927; 1941904; 8666038; 8340611; 12388625; 7086683; 15674847
HyperglycaemiaAlanine aminotransferase 2Q8TD30Not Available6870927; 1941904; 8666038; 8340611; 12388625; 7086683; 15674847
HyperglycaemiaAlanine aminotransferase 1Q8QZR5Not Available6870927; 1941904; 8666038; 8340611; 12388625; 7086683; 15674847
HyperphosphatasaemiaInterleukin-6P08505Not Available25520918
HyperphosphatasaemiaC-C motif chemokine 2P10148Not Available25520918
HyperphosphatasaemiaTumor necrosis factorP06804Not Available25520918
HyperphosphatasaemiaAlpha-2A adrenergic receptorP08913T114489187524; 7913199; 8382844; 6147001; 1957308; 7716792; 12616289
HyperphosphatasaemiaInterleukin-10P18893Not Available25520918
HyperphosphatasaemiaTumor necrosis factorP06804Not Available25884831
HypoxiaUDP-glucuronosyltransferase 2B15P54855Not Available1872890; 1676648; 6284753
HypoxiaSulfotransferase 1B1O43704Not Available1872890; 1676648; 6284753
HypoxiaUDP-glucuronosyltransferase 2B15P54855Not Available16696573; 11854153; 15933229; 16187975
HypoxiaSulfotransferase 1B1P52847Not Available1872890; 1676648; 6284753
Liver injuryTumor necrosis factorP06804Not Available25520918
Liver injuryAlpha-2A adrenergic receptorP08913T114489187524; 7913199; 8382844; 6147001; 1957308; 7716792; 12616289
Liver injuryInterleukin-10P18893Not Available25520918
Liver injuryTumor necrosis factorP06804Not Available25884831
Liver injuryInterleukin-6P08505Not Available25520918
Liver injuryC-C motif chemokine 2P10148Not Available25520918
Lysosomal storage disordersBeta-N-acetylglucosaminidaseP39848Not Available8128494; 8010993; 10746947; 3670277; 3930698; 6690473; 3137115; 3944262; 3579917
Lysosomal storage disordersBeta-glucuronidaseP08236T964138128494; 8010993; 10746947; 3670277; 3930698; 6690473; 3137115; 3944262; 3579917
Renal impairmentCytochrome P450 11B1, mitochondrialP15538T84621Not Available
Renal impairment7-ethoxycoumarin O-deethylaseO23976Not Available6868091; 4035671; 4082192; 1987650; 6868091; 6868092
Respiratory, thoracic and mediastinal disordersMyeloperoxidaseP05164T234712485128; 2485131; 1706962; 1553758; 2986860; 1647886; 3932643; 4035671; 1954382; 7736927; 3708755; 9065819; 6184181; 2908851; 15692622; 6636173; 8779222
SomnolenceCytochrome P450 2E1P05181Not Available12376703; 12376675; 15764585; 15358766; 3973835; 10741631
SomnolenceCytochrome P450 2E1P05181Not Available8470644; 7508362; 10980926
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000268%Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.002207%
Abdominal pain upper07.01.05.0030.000669%
Acidosis14.01.03.0020.000334%
Acute hepatic failure09.01.03.0010.000523%Not Available
Acute respiratory distress syndrome22.01.03.0010.000087%
Administration site reaction12.07.04.011; 08.02.04.011--Not Available
Aggression19.05.01.0010.000201%Not Available
Agitation19.06.02.001; 17.02.05.0120.000401%
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.0030.002541%
Alveolitis22.01.01.001--Not Available
Ammonia increased13.03.01.0230.000035%Not Available
Amylase increased13.05.01.0090.000201%
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000134%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.001--Not Available
Anxiety19.06.02.002--
Apgar score low13.15.01.0120.000134%Not Available
Apnoea22.02.01.0010.000134%
Arrhythmia02.03.02.0010.000070%Not Available
Aspartate aminotransferase increased13.03.01.0060.002809%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atelectasis22.01.02.001--
Azotaemia20.01.01.001--Not Available
Benign prostatic hyperplasia21.04.02.001--Not Available
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