Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abacavir sulfate
Drug ID BADD_D00010
Description Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Indications and Usage For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Marketing Status approved; investigational
ATC Code J05AF06
DrugBank ID DB01048
KEGG ID D00891
MeSH ID C106538
PubChem ID 9843042
TTD Drug ID D0A4IJ
NDC Product Code 68554-0063; 53104-7558; 65862-089; 61876-0718; 65571-0012; 49702-222; 63379-049; 65085-0024; 65862-256; 82245-0207; 64980-405; 17337-0001; 61187-010; 49702-221; 65015-640; 0378-4105; 51079-204; 68554-0032
UNII J220T4J9Q2
Synonyms abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate
Chemical Information
Molecular Formula C14H20N6O5S
CAS Registry Number 188062-50-2
SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.OS(=O)(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Alanine aminotransferase13.03.04.002--Not Available
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Aspartate aminotransferase increased13.03.04.011--
Blood creatine phosphokinase increased13.04.01.001--
Bronchitis22.07.01.001; 11.01.09.001--
Chills15.05.03.016; 08.01.09.001--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Drug hypersensitivity10.01.01.001--Not Available
Ear infection11.01.05.001; 04.03.01.006--Not Available
Fatigue08.01.01.002--
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypersensitivity10.01.03.003--
Hypertriglyceridaemia14.08.02.001--
Lactic acidosis14.01.01.002--Not Available
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Migraine24.03.05.003; 17.14.02.001--Not Available
Musculoskeletal pain15.03.04.007--
Myocardial infarction24.04.04.009; 02.02.02.007--
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