Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name 2-phenylbutyric acid
Drug ID BADD_D00003
Description A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.
Indications and Usage Adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in carbamylphosphate (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase. it is indicated in all neonatal- onset efficiency presenting within the first 28 days of life. Also indicated in patients with late-onset, presenting after the first month of life with a history of hyperammonemic encephalopathy.
Marketing Status Not Available
ATC Code Not Available
DrugBank ID DB06819
KEGG ID Not Available
MeSH ID C039714
PubChem ID 7012
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms 2-phenylbutyric acid | 2-phenylbutanoic acid
Chemical Information
Molecular Formula C10H12O2
CAS Registry Number 90-27-7
SMILES CCC(C1=CC=CC=C1)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acidosis14.01.03.002--
Alkalosis14.01.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaemia01.03.02.001--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Blood uric acid increased13.02.04.001--Not Available
Constipation07.02.02.001--
Deafness04.02.01.001--Not Available
Dermatitis23.03.04.002--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dysgeusia17.02.07.003; 07.14.03.001--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Fatigue08.01.01.002--
Gastritis07.08.02.001--
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hyperchloraemia14.05.08.001--Not Available
Hypernatraemia14.05.04.001--
Hyperphosphataemia14.04.03.007--
Hyperuricaemia14.09.01.003--
Hypoalbuminaemia09.01.02.003; 14.10.01.002--
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.001--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
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