| ADR Ontology |
| ADR Term |
Toxic epidermal necrolysis |
| ADR ID |
BADD_A04359 |
| ADR Hierarchy |
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| Description |
A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. [CTCAE] Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis. | An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. [MeSH] |
| MedDRA Code |
10044223 |
| MeSH ID |
D013262; D013262; D013262
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Synonym |
| Drug eruption Lyell syndrome type | Epidermal necrolysis | Lyell | Lyell syndrome | Lyell's disease | Lyell's syndrome | Necrolysis epidermal | Necrolysis epidermal toxic (Lyell type) | Syndrome Lyell's | TEN | Toxic epideoneal necrolysis | Toxic epidermal necrolysis | Stevens-Johnson Syndrome | Stevens Johnson Syndrome | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Stevens Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Toxic Epidermal Necrolysis Stevens-Johnson Syndrome Spectrum | Toxic Epidermal Necrolysis Stevens Johnson Syndrome | Toxic Epidermal Necrolysis Stevens Johnson Syndrome Spectrum | Toxic Epidermal Necrolysis Stevens-Johnson Syndrome | Stevens Johnson Syndrome Toxic Epidermal Necrolysis | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis | Mycoplasma-Induced Stevens-Johnson Syndrome | Mycoplasma Induced Stevens Johnson Syndrome | Stevens-Johnson Syndrome, Mycoplasma-Induced | Syndrome, Mycoplasma-Induced Stevens-Johnson | Mycoplasma-Induced Stevens Johnson Syndrome | Drug-Induced Stevens Johnson Syndrome | Drug Induced Stevens Johnson Syndrome | Drug-Induced Stevens-Johnson Syndrome | Drug-Induced Stevens-Johnson Syndromes | Stevens-Johnson Syndrome, Drug-Induced | Stevens-Johnson Syndromes, Drug-Induced | Epidermal Necrolysis, Toxic | Epidermal Necrolyses, Toxic | Necrolyses, Toxic Epidermal | Necrolysis, Toxic Epidermal | Toxic Epidermal Necrolyses | Toxic Epidermal Necrolysis | Scalded Skin Syndrome, Nonstaphylococcal | Lyell's Syndrome | Lyell Syndrome | Lyell's Syndromes | Syndrome, Lyell's | Syndromes, Lyell's | Nonstaphylococcal Scalded Skin Syndrome |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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