Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amlodipine
Drug ID BADD_D00121
Description Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers [A175327]. Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure [A175321]. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Indications and Usage For the treatment of hypertension and chronic stable angina.
Marketing Status Prescription; Discontinued
ATC Code C08CA01
DrugBank ID DB00381
KEGG ID D07450
MeSH ID D017311
PubChem ID 2162
NDC Product Code 52652-5001; 46287-035
Synonyms Amlodipine | Amlodipine, (+-)-Isomer | Amlodipine Besylate | Amlodipine, (+-)-Isomer, Maleate (1:1) | Amlodipine, (S)-Isomer, Maleate (1:1) | Amlodis | Astudal | Norvasc | Istin | Amlor | Amlodipine Maleate | Amlodipine Maleate (1:1) | Amlodipine, (R)-Isomer
Chemical Information
Molecular Formula C20H25ClN2O5
CAS Registry Number 88150-42-9
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000092%
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.0100.000046%Not Available
Abdominal pain upper07.01.05.0030.000199%
Abnormal dreams19.02.03.001; Available
Abortion spontaneous18.01.04.001--Not Available
Accommodation disorder06.02.04.001--Not Available
Acute myocardial infarction24.04.04.001; Available
Acute respiratory failure22.02.06.001; Available
Agranulocytosis01.02.03.0010.000031%Not Available
Alanine aminotransferase increased13.03.01.0030.000138%
Altered state of consciousness19.07.01.003; Available
Amaurosis06.02.02.0080.000031%Not Available
Amaurosis fugax24.04.06.006;; Available
Anaphylactic reaction24.06.03.006;
Anaphylactic shock10.01.07.002; Available
Anaphylactoid reaction24.06.03.007; Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Ankle fracture15.08.03.005;
Anuria20.01.03.0020.000123%Not Available
Aortic aneurysm24.02.03.0010.000046%Not Available
Aortic stenosis24.04.01.0010.000046%Not Available
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