Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amifostine
Drug ID BADD_D00102
Description A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Indications and Usage For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
Marketing Status Prescription; Discontinued
ATC Code V03AF05
DrugBank ID DB01143
KEGG ID C06819
MeSH ID D004999
PubChem ID 2141
TTD Drug ID D06CIE
NDC Product Code 65124-0002; 76310-017; 60269-275; 22568-8865; 62756-127; 46439-8768; 61662-0003
Synonyms Amifostine | APAETP | Aminopropylaminoethylthiophosphoric Acid | S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid | Gammaphos | Ethiofos | Amifostine Disodium Salt | Amifostine Monohydrate | Amifostine Trihydrate | Aminopropylaminoethylthiophosphate | Aminopropyl Aminoethylthiophosphate | Ethyol | NSC-296961 | NSC 296961 | NSC296961 | Amifostine Anhydrous | Ethiofos Anhydrous | WR-2721 | WR 2721 | WR2721 | YM-08310 | YM 08310 | YM08310 | Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate | Amifostine Monohydrochloride
Chemical Information
Molecular Formula C5H15N2O3PS
CAS Registry Number 20537-88-6
SMILES C(CN)CNCCSP(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Atrial fibrillation02.03.03.002--
Blood calcium decreased13.11.01.002--Not Available
Blood pressure diastolic decreased13.14.03.003--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema multiforme10.01.03.015; 23.03.01.003--
Extrasystoles02.03.02.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.008--Not Available
Feeling hot08.01.09.009--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Hiccups22.02.04.002; 07.01.06.009--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypocalcaemia14.04.01.004--
Hypoparathyroidism14.04.01.007; 12.02.15.001; 05.04.02.001--
Hypotension24.06.03.002--
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