Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal adhesions12.02.03.006; Available
Abdominal discomfort07.01.06.0010.002157%Not Available
Abdominal distension07.01.04.0010.000524%
Abdominal pain07.01.05.0020.001347%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.001453%
Acrochordon23.10.01.005; Available
Actinic keratosis23.01.06.0010.000418%Not Available
Acute myocardial infarction24.04.04.001; Available
Acute respiratory failure22.02.06.001; Available
Adrenal disorder05.01.03.0010.000066%Not Available
Adrenal insufficiency14.11.01.004;
Alcohol abuse19.07.06.0010.000154%Not Available
Amaurosis fugax24.04.06.006;; Available
Anaemia macrocytic14.12.01.002; Available
Anal fistula07.11.05.0020.000044%
Anastomotic ulcer12.02.03.001;
Anger19.04.02.001--Not Available
Angina pectoris24.04.04.002;
Angina unstable24.04.04.004; Available
Angioedema22.04.02.008;; Available
Angle closure glaucoma06.03.01.0010.000044%Not Available
Anhedonia19.15.02.0070.000770%Not Available
Aortic aneurysm24.02.03.0010.000132%Not Available
Aortic dissection24.02.03.0020.000044%Not Available
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