Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal adhesions12.02.03.006; 07.07.03.0010.000303%Not Available
Abdominal discomfort07.01.06.0010.003940%Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.005153%
Abdominal pain lower07.01.05.0100.000909%Not Available
Abdominal pain upper07.01.05.0030.003738%
Abscess11.01.08.0010.002425%Not Available
Acne23.02.01.001--Not Available
Acrochordon23.10.01.005; 16.26.01.0050.000606%Not Available
Actinic keratosis23.01.06.0010.001920%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.001--Not Available
Acute prerenal failure20.01.03.001; 24.06.02.0030.000202%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000158%Not Available
Acute sinusitis22.07.03.013; 11.01.13.0120.001920%Not Available
Adrenal disorder05.01.03.0010.000303%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000404%
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.0070.000808%Not Available
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amaurosis fugax17.08.04.002; 06.02.02.005; 24.04.06.0060.000202%Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Amnesia17.03.02.001; 19.20.01.0010.002627%
Anaemia01.03.02.0010.015155%
Anaemia macrocytic14.12.01.002; 01.03.02.0020.000505%Not Available
Anal fistula07.11.05.0020.000202%
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anastomotic ulcer12.02.03.001; 07.04.04.003--
Angina pectoris24.04.04.002; 02.02.02.0020.001617%
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