Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amoxicillin
Drug ID BADD_D00129
Description Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.[A190648] Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin.[A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Indications and Usage For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Marketing Status Prescription; Discontinued
ATC Code J01CA04
DrugBank ID DB01060
KEGG ID D00229
MeSH ID D000658
PubChem ID 33613
TTD Drug ID D0F6EO
NDC Product Code 16714-299; 63187-729; 68071-2323; 67296-1126; 70882-114; 63187-335; 50090-0407; 70518-1413; 70934-672; 50090-1826; 65862-016; 72789-225; 72789-077; 63187-186; 72189-285; 55657-106; 0093-3109; 68071-1526; 68071-4734; 45865-594; 65862-707; 68788-9949; 68071-1675; 50090-1794; 67296-1659; 61919-716; 68071-1817; 70847-530; 70882-113; 61919-041; 63187-044; 16714-298; 68071-4548; 50090-4260; 72508-205; 68071-2364; 63187-043; 68788-7318; 68071-4953; 65862-014; 50090-1797; 68071-2397; 65862-071; 52115-001; 65862-015; 0143-9889; 63187-200; 50090-4929; 63629-7585; 57237-033; 50090-1513; 70518-2191; 68071-4851; 68071-4704; 0143-9887; 50090-2251; 0781-5061; 63187-343; 0143-9886; 55289-182; 68071-4920; 70518-2188; 53002-1369; 68071-4567; 68071-4982; 50090-4320; 43063-820; 70934-064; 53002-2160; 0143-9888; 65862-274; 63629-7582; 71205-266; 63629-7584; 0093-4160; 50090-1795; 66267-871; 50090-0404; 0093-4161; 53002-0130; 50090-1807; 68071-1760; 0143-9938; 59115-041; 0143-9939; 68071-4907; 71205-507; 68788-7414; 76420-003; 65862-706; 0781-6156; 67296-1156; 68071-5019; 68071-4064; 63187-262; 68071-4455; 63187-195; 70518-3234; 43063-341; 68071-4574; 0781-5060; 72789-075; 61919-401; 65862-017; 68071-5127; 0781-6041; 57237-028; 43063-563; 68788-9017; 53002-2091; 70518-2190; 50090-0713; 63187-027; 68071-3292; 68071-4698; 68071-2604; 50090-3516; 43063-915; 70518-3228; 50090-1086; 63629-7587; 50090-1347; 53002-2080; 0093-2264; 70847-550; 68788-9948; 68071-2423; 63187-029; 68788-6374; 0093-2267; 68071-2558; 71205-422; 0781-6157; 70518-3294; 42708-112; 50090-1511; 50090-0712; 50090-1796; 55289-020; 43063-574; 50090-0709; 72789-074; 50090-0858; 68071-1789; 57237-030; 68071-4468; 68071-1761; 68071-3343; 63629-7589; 68071-4581; 70934-054; 70934-038; 70934-033; 0781-2613; 42708-078; 70934-087; 57237-031; 61919-015; 0093-3107; 54348-550; 55657-101; 61919-623; 72789-078; 63187-399; 66267-993; 68788-9019; 55289-019; 0781-2020; 71205-035; 42708-076; 68071-2320; 50090-0301; 71205-177; 50090-1595; 76420-138; 0093-2268; 53002-2090; 50090-1512; 0143-9285; 61919-994; 72789-224; 50090-1596; 68071-5148; 68788-7141; 68071-4971; 50090-0303; 66267-994; 50090-0405; 63187-880; 71205-436; 68071-4086; 0093-2263; 42708-010; 70934-140; 68788-6369; 61919-135; 50090-5863; 68788-9018; 57237-029; 50090-0455; 61919-672; 70934-084; 76420-192; 68071-4969; 65862-070; 72508-225; 70934-310; 68071-5096; 68071-5109; 50090-4078; 59651-099; 67296-0986; 68071-4741; 50090-5880; 63629-7588; 50090-4325; 70934-154; 50090-0711; 63187-013; 63187-295; 68071-4796; 43063-885; 0093-4155; 76420-112; 50090-0714; 57237-032; 63187-325; 68071-4693; 50090-0406; 43063-017; 68788-7812; 0781-6039; 50090-1514; 63187-591; 70934-407; 68071-3119; 50090-5215; 50090-0411; 68071-1826; 68071-4724; 68788-7323; 50090-0288; 68071-4696
Synonyms Amoxicillin | Amoxycillin | Amoxicilline | Amoxicillin Monopotassium Salt | Hydroxyampicillin | Amoxicillin Sodium | Amoxicillin Monosodium Salt | Amoxicillin, (R*)-Isomer | Amoxicillin Anhydrous | Actimoxi | BRL-2333 | BRL 2333 | BRL2333 | Clamoxyl | Penamox | Clamoxyl Parenteral | Clamoxyl G.A. | Polymox | Trimox | Wymox | Amoxicillin Trihydrate | Amoxil
Chemical Information
Molecular Formula C16H19N3O5S
CAS Registry Number 26787-78-0
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperphosphatasaemiaC-X-C chemokine receptor type 3P49682T2531525998949
HyperphosphatasaemiaC-C chemokine receptor type 9P51686T9787325998949
HyperphosphatasaemiaC-C chemokine receptor type 4P51679T0695525998949
Liver injuryC-X-C chemokine receptor type 3P49682T2531525998949
Liver injuryC-C chemokine receptor type 9P51686T9787325998949
Liver injuryC-C chemokine receptor type 4P51679T0695525998949
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.000747%
Abdominal pain upper07.01.05.0030.000565%
Abdominal rigidity07.01.05.0110.000020%Not Available
Abortion spontaneous18.01.04.0010.002614%Not Available
Acne23.02.01.001--Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.000091%Not Available
Acute hepatic failure09.01.03.0010.000026%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute psychosis19.03.01.0010.000040%Not Available
Acute respiratory distress syndrome22.01.03.0010.000018%
Affective disorder19.04.04.0010.000030%Not Available
Ageusia17.02.07.001; 07.14.03.0030.000040%Not Available
Aggression19.05.01.0010.000182%Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.0010.000111%Not Available
Akathisia19.06.02.006; 17.01.02.002--
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.001322%
Anaphylactic shock24.06.02.004; 10.01.07.0020.001292%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.000030%Not Available
Angioedema23.04.01.001; 10.01.05.0090.001655%Not Available
Anhedonia19.15.02.007--Not Available
Anosmia22.04.03.006; 17.04.04.0010.000020%
Anuria20.01.03.0020.000050%Not Available
Anxiety19.06.02.002--
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