Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amphetamine
Drug ID BADD_D00130
Description Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 and first synthesized by 1927. After being proven to reduce drug-induced anesthesia and produce arousal and insomnia, amphetamine racemic mix was registered by Smith, Kline and French in 1935. Amphetamine structure presents one chiral center and it exists in the form of dextro- and levo-isomers.[A18540] The first product of Smith, Kline and French was approved by the FDA on 1976.[L5194] During World War II, amphetamine was used to promote wakefulness in the soldiers. This use derived into a large overproduction of amphetamine and all the surplus after the war finalized ended up in the black market, producing the initiation of the illicit abuse.[A18540]
Indications and Usage For treatment of Attention Deficit Disorder with Hyperactivity (ADDH), narcolepsy, and exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction for patients refractory to alternative therapy.
Marketing Status Prescription; Discontinued
ATC Code N06BA01
DrugBank ID DB00182
KEGG ID D07445
MeSH ID D000661
PubChem ID 3007
TTD Drug ID D05BMG
NDC Product Code 70165-005; 70165-025; 70165-015; 27808-109; 27808-108; 27808-102; 70165-030; 69452-227; 69452-228; 70165-010; 69238-1563; 69238-1564; 27808-106; 70165-020; 27808-110
Synonyms Amphetamine | Amfetamine | Phenopromin | Desoxynorephedrin | Phenamine | Centramina | Fenamine | Mydrial | Thyramine | Amphetamine Sulfate | Sulfate, Amphetamine | Amphetamine Sulfate (2:1) | l-Amphetamine | l Amphetamine | levo-Amphetamine | levo Amphetamine | Levoamphetamine
Chemical Information
Molecular Formula C9H13N
CAS Registry Number 300-62-9
SMILES CC(CC1=CC=CC=C1)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.024655%
Aggression19.05.01.0010.073964%Not Available
Agitation19.06.02.001; 17.02.05.0120.041091%
Alopecia23.02.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.0020.016437%
Arrhythmia02.03.02.0010.016437%Not Available
Asthenia08.01.01.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic increased13.14.03.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bruxism19.11.03.001; 07.01.06.008--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.017151%Not Available
Cardiogenic shock02.05.01.003; 24.06.02.0060.016437%Not Available
Cardiomyopathy02.04.01.0010.004288%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.004288%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Coma17.02.09.0010.032873%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.021439%Not Available
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.0020.024655%
Depression19.15.01.0010.032873%
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drug abuse19.07.02.0100.115771%Not Available
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