Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetylsalicylic acid
Drug ID BADD_D00033
Description Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
Indications and Usage For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
Marketing Status Prescription; OTC; Discontinued
ATC Code A01AD05; B01AC06; N02BA01
DrugBank ID DB00945
KEGG ID D00109
MeSH ID D001241
PubChem ID 2244
NDC Product Code 73678-160
Synonyms Aspirin | Acetylsalicylic Acid | Acid, Acetylsalicylic | 2-(Acetyloxy)benzoic Acid | Acylpyrin | Aloxiprimum | Colfarit | Dispril | Easprin | Ecotrin | Endosprin | Magnecyl | Micristin | Polopirin | Polopiryna | Solprin | Solupsan | Zorprin | Acetysal
Chemical Information
Molecular Formula C9H8O4
CAS Registry Number 50-78-2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisCellular tumor antigen p53P10361Not AvailableNot Available
ApoptosisNuclear factor NF-kappa-B p105 subunitP19838T40192Not Available
Capillary leak syndromeAngiopoietin-related protein 4Q9BY76T98635Not Available
Gastrointestinal tract mucosal discolourationVimentinP08670Not AvailableNot Available
Haemorrhagic disorderMyeloperoxidaseP05164T23471Not Available
InflammationsProstaglandin G/H synthase 2P35355Not AvailableNot Available
InflammationsProstaglandin E synthase 3Q15185Not AvailableNot Available
NecrosisAngiopoietin-related protein 4Q9BY76T98635Not Available
Post thrombotic syndromeThromboxane A2 receptorP21731T76198Not Available
Surgical and medical proceduresIntegrin beta-3P05106T26457Not Available
Surgical and medical proceduresIntegrin alpha-IIbP08514Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000092%Not Available
Abdominal pain07.01.05.0020.000184%
Abdominal pain upper07.01.05.0030.000138%
Abortion spontaneous18.01.04.0010.000092%Not Available
Adrenal insufficiency05.01.02.001;
Anaphylactic shock24.06.02.004; Available
Angioedema23.04.01.001; Available
Asthenia08.01.01.0010.000138%Not Available
Asthma22.03.01.002; Available
Blindness17.17.01.003; Available
Blood cholesterol increased13.12.01.002--
Bradycardia02.03.02.0020.000138%Not Available
Breast feeding26.05.01.001--Not Available
Cardiac arrest02.03.04.0010.000092%
Cardio-respiratory arrest22.02.06.007; Available
Cerebral haemorrhage17.08.01.003; Available
Cerebral infarction24.04.06.002; Available
Cerebrovascular accident17.08.01.007;
Chest discomfort22.02.08.001;; Available
Chest pain22.02.08.003;; Available
Coagulopathy01.01.02.001--Not Available
Coma17.02.09.0010.000036%Not Available
Confusional state19.13.01.001;
Deafness04.02.01.001--Not Available
Dermatitis23.03.04.002--Not Available
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