Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aliskiren
Drug ID BADD_D00073
Description Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension.[A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007.[L14018] Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in conjunction with other antihypertensive agents.[A203624]
Indications and Usage For the treatment of hypertension, to lower blood pressure.
Marketing Status Prescription
ATC Code C09XA02
DrugBank ID DB09026
KEGG ID D03208
MeSH ID C446481
PubChem ID 5493444
NDC Product Code 49884-425; 49884-424
Synonyms aliskiren | rasilez | Tekturna | CGP 060536B | CGP060536B | CGP-060536B | 2(S),4(S),5(S),7(S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-(4-methoxy-3-(3-methoxypropoxy)phenyl)octanamid hemifumarate | SPP100
Chemical Information
Molecular Formula C30H53N3O6
CAS Registry Number 173334-57-1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.002793%
Abdominal pain07.01.05.0020.005586%
Abdominal pain upper07.01.05.0030.004189%
Abdominal tenderness07.01.05.0040.002793%Not Available
Acute myocardial infarction24.04.04.001; Available
Anaphylactic shock24.06.02.004; Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Arrhythmia02.03.02.0010.001093%Not Available
Asthenia08.01.01.0010.008378%Not Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.0020.002793%
Back pain15.03.04.0050.005586%
Blood creatinine increased13.13.01.0040.012568%
Blood potassium increased13.11.01.0110.002793%Not Available
Blood pressure increased13.14.03.0050.005586%Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Bradycardia02.03.02.0020.002793%Not Available
Bundle branch block left02.03.01.0070.002793%Not Available
Cardiac failure02.05.01.0010.005828%
Cardiac failure congestive02.05.01.0020.000729%Not Available
Cardiomegaly02.04.02.0010.000729%Not Available
Cardiomyopathy02.04.01.0010.000729%Not Available
Cerebrovascular accident17.08.01.007;
Chest discomfort22.02.08.001;; Available
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