Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aripiprazole
Drug ID BADD_D00165
Description Aripiprazole is an atypical antipsychotic orally indicated for treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's[Label]. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania[Label]. Aripiprazole exerts its effects through agonism of dopaminic and 5-HT1A receptors and antagonism of alpha adrenergic and 5-HT2A receptors[Label,A4393]. Aripiprazole was given FDA approval on November 15, 2002[L6136].
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AX12
DrugBank ID DB01238
KEGG ID D01164
MeSH ID D000068180
PubChem ID 60795
TTD Drug ID D0H3HM
NDC Product Code 48433-120; 59148-007; 68554-0095; 62332-099; 60505-2675; 59148-010; 76282-045; 68382-439; 27241-056; 71335-1903; 31722-829; 63629-7017; 46708-256; 16714-787; 60505-2674; 17856-0570; 59651-110; 43598-554; 70518-3380; 48433-115; 65862-662; 65862-680; 50090-4817; 65162-896; 33342-123; 70518-2565; 68788-7162; 13668-219; 76282-049; 71335-1980; 60429-451; 0904-6511; 0904-6656; 31722-820; 50370-0009; 48433-117; 16714-145; 50090-4160; 68554-0020; 55289-251; 70934-662; 59148-030; 43353-148; 46602-0045; 67877-432; 63629-7003; 46708-260; 68071-5062; 50370-0044; 70518-2508; 71335-1893; 42043-401; 27241-052; 50228-325; 68788-7733; 50090-4800; 46602-1031; 63739-413; 72865-185; 43547-304; 0904-6510; 43598-966; 59148-034; 70771-1454; 43547-303; 71335-0412; 27241-053; 60687-157; 29300-176; 43598-968; 76282-048; 43598-558; 59116-2901; 70771-1451; 46602-1029; 59148-018; 68382-083; 67877-433; 43547-306; 70518-1303; 50228-477; 69452-339; 68788-7808; 16729-279; 65162-902; 63415-0085; 70518-2765; 59148-011; 50228-324; 27241-054; 12828-0088; 70771-1456; 29300-178; 50090-5840; 67877-434; 43598-970; 50228-478; 62332-100; 50090-5839; 33342-126; 60505-2677; 46602-1032; 46602-0010; 31722-827; 72865-153; 72865-181; 53104-7628; 59148-045; 43598-967; 70518-2806; 46602-0006; 68788-7006; 46602-0026; 59148-029; 43598-555; 64220-112; 70518-2950; 33342-124; 50228-329; 70518-2584; 50090-4863; 16714-788; 60687-168; 70518-2869; 60505-2673; 13668-221; 43547-305; 43353-140; 72865-154; 16714-783; 72865-184; 33342-127; 62332-098; 71335-1935; 65862-666; 13668-216; 16729-280; 43353-180; 68382-085; 29300-179; 16714-141; 63629-6999; 65162-899; 65862-661; 43598-969; 0904-6514; 70518-2580; 16714-144; 70518-2567; 70518-2825; 70518-2736; 16714-146; 46602-0007; 66689-735; 58032-2005; 59148-072; 13668-217; 60429-446; 59148-032; 63187-965; 31722-830; 71335-1364; 65372-1121; 62332-097; 63739-070; 70518-2515; 16714-785; 50228-328; 70518-2536; 72865-183; 62332-101; 70518-2557; 0615-8375; 65862-663; 72865-182; 33342-122; 60505-2676; 43598-556; 71335-1682; 46602-0072; 50090-3941; 46602-0009; 43598-559; 46708-259; 68382-082; 50090-4936; 65691-0052; 43547-302; 46602-0008; 71205-480; 43598-965; 68382-084; 60429-449; 43547-307; 71335-1832; 71335-1515; 17856-0110; 50370-0055; 59148-006; 53747-031; 50228-327; 60505-3075; 50268-088; 70518-1263; 70518-2820; 13668-218; 50228-476; 72865-158; 50090-4665; 16729-278; 16714-786; 59148-008; 70518-2897; 72761-020; 68788-8089; 31722-819; 68788-7076; 65862-664; 70518-3011; 60687-213; 46602-0011; 72865-157; 29300-180; 76072-1002; 70518-2921; 46602-1030; 16729-282; 62332-102; 76282-047; 65841-140; 71335-1688; 70771-1455; 71335-1513; 46708-254; 48433-119; 60429-450; 65162-898; 60505-0404; 43353-147; 59148-031; 63739-074; 70771-1452; 46708-258; 0904-6509; 46708-255; 65162-897; 50268-091; 27241-051; 59148-019; 46602-1034; 76282-046; 46602-1033; 12658-0576; 0615-8259; 48433-118; 72865-155; 50228-480; 62332-103; 68788-7063; 0904-6512; 27241-055; 63629-7108; 50268-089; 53808-1101; 63739-078; 70518-3004; 68382-086; 70518-1421; 72865-180; 70518-2827; 50268-092; 16729-283; 66603-706; 68071-2394; 69452-338; 16729-281; 12658-0577; 70518-2514; 67877-431; 72865-156; 49706-1889; 68788-7749; 65862-665; 50268-087; 70518-2958; 69037-0058; 50228-475; 33342-125; 58623-0127; 63739-069; 70771-1453; 60429-447; 14445-019; 60429-448; 43598-557; 66603-705; 76282-044; 46602-0025; 50268-090; 71335-1687; 29300-177; 67835-0009; 31722-828; 71335-1892; 46708-261; 54838-570; 70518-0970; 60687-202; 71205-392; 63629-7774; 70518-3090; 67877-430; 16714-784; 29300-175; 70518-2974; 16714-143; 60687-179; 59148-033; 62332-104; 67877-435; 42043-400; 65096-0107; 13668-220; 16714-142; 46708-257; 50228-326; 48433-116; 65162-893; 59148-009; 50228-479; 0904-6513; 60687-191; 65162-901; 59116-2900; 71335-1711; 70518-2643
Synonyms Aripiprazole | 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone | Aripiprazol | Abilify | OPC 14597 | OPC-14597
Chemical Information
Molecular Formula C23H27Cl2N3O2
CAS Registry Number 129722-12-9
SMILES C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.004--Not Available
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abnormal faeces07.01.03.001--Not Available
Abnormal sensation in eye06.01.01.0010.000572%Not Available
Abnormal weight gain14.03.02.0100.000381%Not Available
Abortion18.01.01.0010.003433%Not Available
Abortion missed18.01.01.0020.000381%Not Available
Abortion spontaneous18.01.04.0010.024793%Not Available
Accommodation disorder06.02.04.0010.000572%Not Available
Acne23.02.01.001--Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.001335%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute psychosis19.03.01.0010.001526%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000348%Not Available
Acute sinusitis22.07.03.013; 11.01.13.0120.000381%Not Available
Affective disorder19.04.04.0010.001716%Not Available
Aggression19.05.01.0010.016783%Not Available
Agitation19.06.02.001; 17.02.05.0120.017927%
Agoraphobia19.06.03.004--Not Available
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.022504%
Akinesia17.01.02.0030.000381%Not Available
Alanine aminotransferase abnormal13.03.01.0010.000381%Not Available
Alanine aminotransferase increased13.03.01.0030.003624%
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