Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alprazolam
Drug ID BADD_D00085
Description Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.[A18125] Alprazolam's adverse effects are generally related to the sedation it can cause.[A18125] Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death.[A18125] Alprazolam was given FDA approval on October 16, 1981.[L6148]
Indications and Usage Alprazolam is indicated for the acute treatment of generalized anxiety disorder in adults.[L34783] Alprazolam is also indicated, either as a standard or extended-release formulation, for the treatment of panic disorder with or without agoraphobia in adults.[L34783, L34788] Alprazolam may also be prescribed off-label for insomnia, premenstrual syndrome, and depression.[A177973]
Marketing Status approved; illicit; investigational
ATC Code N05BA12
DrugBank ID DB00404
KEGG ID D00225
MeSH ID D000525
PubChem ID 2118
TTD Drug ID D0L9GG
NDC Product Code 72789-151; 49452-0295; 0009-0055; 45865-972; 49884-213; 0228-2039; 0228-3084; 53002-3952; 59762-3719; 60760-550; 63187-966; 68071-2220; 68071-5243; 68788-7595; 70518-2870; 70518-3763; 71335-1386; 71335-1669; 71335-9666; 71335-9667; 71610-696; 72189-213; 0228-2031; 65862-678; 49884-110; 51991-706; 0228-3086; 53002-0340; 59762-0066; 59762-3722; 60760-678; 65862-677; 67296-1748; 68071-2976; 68788-7596; 0054-3068; 71205-652; 71335-0849; 71335-1576; 71335-1839; 72189-240; 72789-313; 0781-1079; 80425-0110; 42816-0055; 42816-0094; 65862-454; 65862-457; 71554-013; 59762-0057; 61919-005; 63187-444; 63187-445; 63187-916; 65162-813; 68071-2965; 71205-284; 71205-718; 71335-1907; 65162-810; 71335-1291; 71610-112; 0615-8295; 0228-2029; 12780-4630; 64330-013; 0009-0068; 49884-214; 50090-2819; 50090-5258; 0228-2027; 51991-705; 51991-707; 59762-3721; 65862-676; 67296-0757; 67544-414; 68071-2236; 68071-2794; 70518-3259; 70954-510; 71205-614; 71335-1894; 72189-121; 72189-450; 0781-1061; 12828-0040; 42816-0029; 42816-0057; 0009-0057; 0009-0059; 43063-609; 45865-424; 50090-5262; 0228-4019; 0228-4022; 55700-929; 59762-0059; 59762-3720; 63187-443; 65862-456; 68071-2292; 68071-4831; 70954-509; 70954-511; 71205-227; 71335-1477; 80425-0161; 0009-5144; 42816-0090; 65015-634; 65862-679; 0009-0066; 50090-5078; 51991-704; 0228-3083; 67544-415; 68071-5263; 68788-8410; 70518-2785; 70518-3730; 0781-1077; 80425-0099; 80425-0100; 80425-0284; 42816-0059; 42816-0066; 42816-0068; 63187-518; 68071-5113; 68071-5128; 68788-7613; 68788-9682; 71335-1092; 71610-113; 72789-042; 83008-010; 65862-455; 0009-0029; 0009-0090; 45865-993; 49884-111; 0228-4024; 63187-971; 65162-809; 65162-812; 68788-7594; 68788-8394; 71335-2133; 71335-9660; 49999-252; 50090-2896; 50090-5261; 63187-225; 67544-347; 68071-2966; 68788-8414; 70954-508; 71335-0427; 71335-0920; 71335-1129; 72162-1059; 72789-024; 72789-328; 0781-1089; 57218-312; 0009-0094; 0228-3087; 0228-4025; 53002-4181; 55289-523; 59762-0068
UNII YU55MQ3IZY
Synonyms Alprazolam | Alprazolan | Trankimazin | U-31,889 | U31,889 | Xanax | Alprox | Esparon | Cassadan | D-65MT | D65MT | Kalma | Novo-Alprazol | Novo Alprazol | Nu-Alpraz | Nu Alpraz | Ralozam | Tafil | Apo-Alpraz | Apo Alpraz
Chemical Information
Molecular Formula C17H13ClN4
CAS Registry Number 28981-97-7
SMILES CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Acute hepatic failure09.01.03.0010.000097%Not Available
Acute respiratory distress syndrome22.01.03.001; 24.03.02.034; 10.02.01.0670.000078%
Affective disorder19.04.04.0010.000134%Not Available
Aggression19.05.01.0010.000730%Not Available
Agitation19.06.02.001; 17.02.05.0120.001303%
Agoraphobia19.06.03.0040.000019%Not Available
Akathisia19.06.02.006; 17.01.02.0020.000078%
Akinesia17.01.02.0030.000019%Not Available
Alcohol abuse19.07.06.0010.000379%Not Available
Alcoholism19.07.06.0060.000109%Not Available
Altered state of consciousness19.07.01.003; 17.02.04.0010.000699%Not Available
Amnesia19.20.01.001; 17.03.02.0010.000324%
Anaphylactic shock10.01.07.002; 24.06.02.0040.000165%Not Available
Anger19.04.02.0010.000349%Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.0010.000058%Not Available
Anticholinergic syndrome17.05.01.0010.000078%Not Available
Anuria20.01.03.0020.000049%Not Available
Anxiety19.06.02.0020.002543%
Aortic aneurysm24.02.03.0010.000019%Not Available
Aortic valve incompetence02.07.03.0010.000019%Not Available
Apathy19.04.04.0020.000111%Not Available
Aphasia19.21.01.001; 17.02.03.0010.000107%
Apraxia17.02.03.002; 19.21.01.0020.000068%Not Available
Aptyalism07.06.01.001--Not Available
Areflexia17.02.01.0010.000068%Not Available
Arthralgia15.01.02.001--
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ADReCS-Target
Drug Name ADR Term Target
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