Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Mitral valve incompetence
ADR ID BADD_A02830
ADR Hierarchy
02      Cardiac disorders
02.07      Cardiac valve disorders
02.07.01      Mitral valvular disorders
02.07.01.002      Mitral valve incompetence
Description Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation. [MeSH]
MedDRA Code 10027727
MeSH ID D008944; D008944; D008944
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Mitral incompetence | Mitral insufficiency | Mitral regurgitation | Mitral valve incompetence | Rheumatic mitral incompetence | Rheumatic mitral insufficiency | Mitral valve incompetence aggr. | Mitral valve insufficiency | Mitral Valve Insufficiency | Insufficiency, Mitral Valve | Valve Insufficiency, Mitral | Mitral Valve Regurgitation | Regurgitation, Mitral Valve | Valve Regurgitation, Mitral | Mitral Regurgitation | Regurgitation, Mitral | Mitral Valve Incompetence | Incompetence, Mitral Valve | Valve Incompetence, Mitral | Mitral Incompetence | Incompetence, Mitral | Mitral Insufficiency | Insufficiency, Mitral
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.003233%
BADD_D00073Aliskiren0.002793%
BADD_D00076Allopurinol0.000264%
BADD_D00085Alprazolam0.000293%
BADD_D00100Ambrisentan--
BADD_D00115Amiodarone0.001786%
BADD_D00142Anastrozole0.000754%
BADD_D00151Apixaban--
BADD_D00178Atenolol--
BADD_D00271Bicalutamide0.006444%
BADD_D00277Bisoprolol0.000875%
BADD_D00284Bortezomib0.000799%
BADD_D00304Bromocriptine0.012094%
BADD_D00329Cabergoline0.077071%
BADD_D00349Capecitabine0.001332%
BADD_D00364Carboplatin0.000799%
BADD_D00367Carfilzomib0.001066%
BADD_D00405Ceftriaxone0.020426%
BADD_D00410Celecoxib0.000230%
BADD_D00474Cisplatin0.000533%
BADD_D00475Citalopram0.000208%
BADD_D00501Clonazepam0.000323%
BADD_D00504Clopidogrel0.000147%
BADD_D00511Clozapine0.061653%
BADD_D00564Dabigatran etexilate0.006329%
BADD_D00581Daptomycin0.000319%
BADD_D00589Dasatinib0.000799%
BADD_D00668Digoxin0.001061%
BADD_D00723Doxorubicin0.001066%
BADD_D00775Enzalutamide--
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