Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Actinic keratosis23.01.06.0010.004025%Not Available
Acute hepatic failure09.01.03.0010.001342%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000525%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.001--Not Available
Acute psychosis19.03.01.0010.002013%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.003354%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000525%Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Agitation17.02.05.012; 19.06.02.0010.006038%
Agranulocytosis01.02.03.0010.005367%Not Available
Akathisia19.06.02.006; 17.01.02.0020.002683%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amnesia19.20.01.001; 17.03.02.0010.005367%
Anaemia01.03.02.0010.016771%
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock24.06.02.004; 10.01.07.0020.006038%Not Available
Aneurysm24.02.01.0010.000525%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.005367%
Angina unstable24.04.04.004; 02.02.02.0040.001342%Not Available
Angioedema23.04.01.001; 10.01.05.0090.010063%Not Available
Ankle fracture15.08.03.005; 12.04.01.0050.002013%
Anosmia22.04.03.006; 17.04.04.001--
Anuria20.01.03.0020.002013%Not Available
Anxiety19.06.02.002--
The 1th Page    1 2 3 4 5    Next   Last    Total 20 Pages