Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal faeces07.01.03.0010.000434%Not Available
Acrochordon23.10.01.005; 16.26.01.005--Not Available
Acute abdomen07.01.06.0150.000087%Not Available
Acute leukaemia16.01.02.001; 01.10.02.0010.000043%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.001627%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000638%Not Available
Adenocarcinoma16.16.01.0040.000087%Not Available
Adenoma benign16.02.02.0010.000087%Not Available
Adrenal disorder05.01.03.0010.000043%Not Available
Adrenal haemorrhage12.01.17.003; 24.07.01.023; 05.01.03.0020.000347%Not Available
Alanine aminotransferase abnormal13.03.04.003--Not Available
Alanine aminotransferase increased13.03.04.005--
Amaurosis06.02.10.0010.000043%Not Available
Amaurosis fugax06.02.10.002; 24.04.06.006; 17.08.04.0020.000152%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Amyloidosis10.02.05.0010.000174%Not Available
Amyotrophic lateral sclerosis17.05.05.0040.000065%Not Available
Anaemia01.03.02.0010.014344%
Anaemia macrocytic14.12.01.002; 01.03.02.0020.000087%Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aneurysm24.02.01.0010.000443%Not Available
Angina pectoris02.02.02.002; 24.04.04.0020.000607%
Anorectal disorder07.03.01.0010.000043%Not Available
Aortic aneurysm24.02.03.0010.000390%Not Available
Aortic aneurysm rupture24.02.03.0030.000217%Not Available
Aortic dissection24.02.03.0020.000347%Not Available
Aortic stenosis24.04.01.0010.000325%Not Available
Aortic thrombosis24.01.09.0010.000130%Not Available
Aortic valve incompetence02.07.03.0010.000108%Not Available
Aortic valve stenosis02.07.03.0040.000195%Not Available
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