Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status Prescription; Discontinued
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 49884-673; 14096-153; 50090-3951; 47848-009; 50742-118; 50090-3157; 59762-1005; 50090-5834; 0093-5420
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.044040%Not Available
Abdominal distension07.01.04.0010.033030%
Abdominal pain07.01.05.0020.055051%
Abdominal pain lower07.01.05.0100.022020%Not Available
Abdominal pain upper07.01.05.003--
Abortion spontaneous18.01.04.0010.088081%Not Available
Acne23.02.01.001--Not Available
Acromegaly24.08.04.004; 15.03.01.018; 14.11.01.029; 05.03.01.0050.077071%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.055051%Not Available
Acute psychosis19.03.01.0010.022020%Not Available
Adenoma benign16.02.02.0010.022020%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.033030%
Aggression19.05.01.0010.022020%Not Available
Agitation17.02.05.012; 19.06.02.001--
Alcoholism19.07.02.0010.022020%Not Available
Alopecia23.02.02.0010.033030%
Alveolitis22.01.01.0010.022020%Not Available
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.0020.055051%
Anxiety19.06.02.0020.088081%
Apathy19.04.04.0020.022020%Not Available
Arrhythmia02.03.02.001--Not Available
Arteriosclerosis24.04.02.0010.005744%Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.044040%Not Available
Arteriovenous fistula24.03.03.0010.044040%Not Available
Arthralgia15.01.02.0010.077071%
Arthritis15.01.01.0010.022020%
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Back pain15.03.04.0050.044040%
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