Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bromocriptine
Drug ID BADD_D00304
Description Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It is indicated for the management of signs and symptoms of Parkinsonian Syndrome. Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. It also causes sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly. Bromocriptine has been associated with pulmonary fibrosis.
Indications and Usage For the treatment of galactorrhea due to hyperprolactinemia, prolactin-dependent menstrual disorders and infertility, prolactin-secreting adenomas, prolactin-dependent male hypogonadism, as adjunct therapy to surgery or radiotherapy for acromegaly or as monotherapy is special cases, as monotherapy in early Parksinsonian Syndrome or as an adjunct with levodopa in advanced cases with motor complications. Bromocriptine has also been used off-label to treat restless legs syndrome and neuroleptic malignant syndrome.
Marketing Status Prescription; Discontinued
ATC Code G02CB01; N04BC01
DrugBank ID DB01200
KEGG ID D03165
MeSH ID D001971
PubChem ID 31101
TTD Drug ID D06YFA
NDC Product Code Not Available
Synonyms Bromocriptine | 2-Bromo-alpha-ergokryptine | 2 Bromo alpha ergokryptine | Bromocryptin | 2-Bromoergokryptine | 2 Bromoergokryptine | Bromocriptin | 2-Bromoergocryptine | 2 Bromoergocryptine | 2-Bromo-alpha-ergocryptine | 2 Bromo alpha ergocryptine | CB-154 | CB 154 | CB154 | Parlodel | 2-Bromoergocryptine Mesylate | 2 Bromoergocryptine Mesylate | Mesylate, 2-Bromoergocryptine | Bromocriptine Mesylate | Mesylate, Bromocriptine | 2-Bromoergocryptine Methanesulfonate | 2 Bromoergocryptine Methanesulfonate | Methanesulfonate, 2-Bromoergocryptine
Chemical Information
Molecular Formula C32H40BrN5O5
CAS Registry Number 25614-03-3
SMILES CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C 4)Br)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.006047%
Abdominal pain upper07.01.05.0030.006047%
Abortion18.01.01.0010.009070%Not Available
Aggression19.05.01.0010.012094%Not Available
Alcohol intolerance14.02.01.001--
Alopecia23.02.02.001--
Amnesia17.03.02.001; 19.20.01.0010.006047%
Anaemia01.03.02.0010.006047%
Anxiety19.06.02.002--
Aortic valve incompetence02.07.03.0010.006047%Not Available
Arrhythmia02.03.02.001--Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.006047%Not Available
Asthenia08.01.01.0010.006047%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blepharospasm17.17.02.001; 06.05.01.001--Not Available
Blood creatine phosphokinase increased13.04.01.0010.006047%
Blood pressure increased13.14.03.0050.006047%Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure02.05.01.0010.001577%
Cardiac failure congestive02.05.01.0020.001577%Not Available
Cardiomegaly02.04.02.0010.001577%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.006047%
Cholecystitis09.03.01.0010.006047%
Cholelithiasis09.03.01.0020.006047%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Delirium19.13.02.0010.006047%
Delusional perception19.10.02.006--Not Available
Depressed level of consciousness17.02.04.0020.006047%
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