Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status approved
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729; D10823; D10824
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 42543-714; 50090-4918; 52605-083; 16729-218; 0024-1171; 68788-8190; 72578-012; 65977-0037; 52605-082; 63187-362; 63629-4728; 70518-0400; 33342-060; 42543-713; 65162-414; 0093-7314; 16729-219; 61919-007; 67296-1840; 50090-2598; 50090-5781; 0024-1332; 61919-737; 70771-1062; 16714-052; 68071-2813; 68071-4138; 71335-0581
UNII A74586SNO7
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000261%
Abdominal pain07.01.05.0020.000954%
Abdominal pain upper07.01.05.0030.000712%
Abdominal tenderness07.01.05.0040.000043%Not Available
Abnormal faeces07.01.03.0010.000021%Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.000032%Not Available
Acute hepatic failure09.01.03.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.001433%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000043%Not Available
Acute respiratory distress syndrome24.03.02.034; 10.02.01.067; 22.01.03.0010.000096%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000096%Not Available
Adenoma benign16.02.02.0010.000021%Not Available
Adrenal haemorrhage24.07.01.023; 05.01.03.002; 12.01.17.0030.000064%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000021%
Ageusia17.02.07.001; 07.14.03.0030.000126%Not Available
Agranulocytosis01.02.03.0010.000160%Not Available
Altered state of consciousness19.07.01.003; 17.02.04.0010.000267%Not Available
Amaurosis06.02.10.0010.000021%Not Available
Anaemia01.03.02.0010.002843%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000107%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.000021%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000332%
Angina unstable24.04.04.004; 02.02.02.0040.000332%Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.000494%Not Available
Anisocytosis01.07.02.0080.000021%Not Available
Anosmia17.04.04.001; 22.04.03.0060.000021%
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.0010.000021%Not Available
Aortic aneurysm rupture24.02.03.0030.000021%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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