Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Atenolol
Drug ID BADD_D00178
Description Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize.[A178429] Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review of patients being treated for primary hypertension shows that atenolol shows a risk ratio of 0.88 for cardiovascular disease risk and a risk ratio of 0.99 for mortality.[A235850,A235855] Similar results have been found in other meta-analyses.[A235860,A235865] A meta-analysis of over 145,000 patients showed the risk of stroke in patients taking atenolol may depend on the age of the patient.[A235865] The use of atenolol may need to be based on more patient factors than hypertension alone.[A235850,A235855,A235860,A235865]
Indications and Usage For the management of hypertention and long-term management of patients with angina pectoris
Marketing Status Prescription; Discontinued
ATC Code C07AB03
DrugBank ID DB00335
KEGG ID D00235
MeSH ID D001262
PubChem ID 2249
TTD Drug ID D01UXC
NDC Product Code 60760-787; 50090-2923; 67296-1589; 70934-142; 65862-169; 53002-2138; 68071-4274; 50090-5741; 50090-5363; 50090-3411; 68788-7784; 68788-7528; 52427-429; 0378-0231; 71335-1108; 51079-685; 48589-0007; 0904-7187; 0615-8026; 65841-024; 70518-0379; 65862-168; 65841-022; 70518-3036; 63187-710; 61919-914; 71335-0954; 55700-754; 68788-7535; 60429-027; 68071-4538; 53002-4108; 70934-537; 68382-022; 65862-170; 70518-0399; 71335-0988; 68788-7616; 67296-1270; 55700-755; 63187-092; 52427-430; 51079-684; 52427-431; 61919-854; 50090-5266; 60760-163; 67544-161; 70934-457; 64980-437; 60760-164; 43063-765; 68382-023; 71205-496; 67296-1288; 60687-605; 68071-4751; 68071-4526; 70518-0351; 70934-219; 67296-1726; 70518-2866; 60429-025; 65841-023; 29300-410; 60429-026; 71335-0912; 70518-2939; 0093-0787; 63629-2626; 0093-0753; 0615-8027; 68071-2248; 51604-0012; 67296-1201; 53002-1138; 0378-0757; 50090-0442; 71335-0540; 68071-1772; 60760-643; 70518-0882; 68071-4766; 70934-458; 68071-1771; 68382-024; 55154-5455; 12660-0007; 51079-759; 68071-4527; 42708-012; 0378-0218; 43353-986; 71335-0668; 61294-9994; 71335-1535; 43063-952; 63629-1785; 71205-229; 72189-135; 50090-3410; 72189-152; 68071-4553; 60760-437; 68788-7876; 63187-537; 67544-240; 57451-1115; 38779-0262; 64980-438; 68645-585; 0615-8373; 61919-664; 71335-1264; 50090-5738; 53002-1004; 51927-2467; 42185-7034; 29300-411; 67296-1732; 68071-5162; 50090-5233; 64980-439; 43063-805; 63187-201; 72189-146; 68071-5033; 67544-332; 70934-177; 0615-8372; 0093-0752; 71335-1616; 53002-2004; 29300-412; 61919-581; 63629-8029; 42708-143; 67296-1558; 60760-642; 60760-256; 43353-834; 50090-5408; 50090-3043; 61919-257; 65841-101; 70518-3007; 53002-1108; 70934-463; 49452-0020; 55154-5511; 72789-144; 71205-096; 61919-279; 50090-5367; 51927-0208
Synonyms Atenolol | Tenormine | Tenormin | ICI-66082 | ICI 66082 | ICI66082
Chemical Information
Molecular Formula C14H22N2O3
CAS Registry Number 29122-68-7
SMILES CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000185%
Abdominal pain07.01.05.0020.000591%
Abdominal pain upper07.01.05.0030.000776%
Abdominal tenderness07.01.05.0040.000074%Not Available
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abortion spontaneous18.01.04.001--Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.000074%
Acute lymphocytic leukaemia16.01.01.001; 01.10.01.0010.000019%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000058%
Affective disorder19.04.04.0010.000222%Not Available
Aggression19.05.01.0010.000480%Not Available
Agitation19.06.02.001; 17.02.05.0120.000924%
Agranulocytosis01.02.03.001--Not Available
Akinesia17.01.02.0030.000074%Not Available
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000296%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000185%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000185%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000148%
Angioedema10.01.05.009; 23.04.01.0010.000407%Not Available
Anuria20.01.03.0020.000296%Not Available
Anxiety19.06.02.0020.000924%
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.0010.000074%
Arrhythmia02.03.02.0010.000665%Not Available
Arrhythmia supraventricular02.03.03.0010.000074%Not Available
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