Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Candesartan cilexetil
Drug ID BADD_D00347
Description Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
Indications and Usage Mendis B, Page SR: Candesartan: widening indications for this angiotensin II receptor blocker? Expert Opin Pharmacother. 2009 Aug;10(12):1995-2007. doi: 10.1517/14656560903092197.
Marketing Status Prescription; Discontinued
ATC Code C09CA06
DrugBank ID DB00796
KEGG ID D00626
MeSH ID C077793
PubChem ID 2540
TTD Drug ID Not Available
NDC Product Code 62559-640; 0378-3224; 62559-643; 62332-341; 49884-659; 0378-3225; 72761-002; 49884-660; 62559-641; 63629-2127; 46708-342; 49884-661; 0378-3232; 68382-191; 70771-1204; 63629-2126; 17228-0032; 62332-342; 70518-2719; 0378-3231; 60687-119; 62332-343; 46708-060; 70771-1207; 60687-241; 70771-1205; 68382-190; 17228-0017; 46708-343; 68382-192; 62559-642; 68382-193; 49884-658; 62332-060; 46708-877; 70771-1206; 17228-0016; 17228-0018; 70518-2884; 64220-114; 60687-130; 46708-341; 52562-100; 65372-1128
Synonyms candesartan cilexetil | 1-(cyclohexylocarbonyloxy)ethyl-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboxylate | 1H-benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)-, hydroxide, inner salt, (+-)- | Parapres | Kenzen | Amias | Blopress | Atacand | TCV 116 | TCV-116
Chemical Information
Molecular Formula C33H34N6O6
CAS Registry Number 145040-37-5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.007710%
Abdominal pain07.01.05.0020.021201%
Abdominal pain upper07.01.05.003--
Acute myocardial infarction24.04.04.001; Available
Acute pulmonary oedema02.05.02.004; Available
Acute respiratory failure22.02.06.001; Available
Ageusia17.02.07.001; Available
Aggression19.05.01.0010.005782%Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Albuminuria20.02.01.001--Not Available
Altered state of consciousness17.02.04.001; Available
Anaphylactic reaction24.06.03.006;
Anaphylactic shock24.06.02.004; Available
Angina pectoris24.04.04.002;
Angioedema10.01.05.009; Available
Angle closure glaucoma06.03.01.001--Not Available
Anuria20.01.03.0020.011564%Not Available
Aortic aneurysm24.02.03.0010.003855%Not Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.0010.005782%Not Available
Arthropathy15.01.01.003--Not Available
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