Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clonazepam
Drug ID BADD_D00501
Description A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop [FDA Label] [L5572, F3763, F3787, F3796]. The agent has also been indicated for treating panic disorder [FDA Label] [A175438, L5572, F3763, F3787, F3796]. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses [FDA Label] [A175438, A175441, L5572, F3763, F3787, F3796]. Since being first patented in 1960 and then released for sale from Roche in the US in 1975 [T469, T472], clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse [FDA Label] [L5572, F3763, F3787, F3796].
Indications and Usage Clonazepam is used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. It can also be used for the treatment of panic disorders.
Marketing Status Prescription; Discontinued
ATC Code N03AE01
DrugBank ID DB01068
KEGG ID D00280
MeSH ID D002998
PubChem ID 2802
TTD Drug ID D0CP4E
NDC Product Code 57664-784; 43063-794; 17856-0834; 0228-3004; 62756-110; 0093-9290; 60429-525; 71335-1843; 63629-8988; 70518-1297; 70518-2334; 51552-1567; 68071-5163; 62332-368; 60687-555; 80425-0125; 0615-8235; 68788-7181; 50090-4299; 60760-273; 68788-7394; 49884-308; 0004-0058; 49884-310; 63629-1207; 68071-4135; 55154-6831; 62332-364; 70518-1521; 71610-084; 43353-308; 71610-366; 43547-408; 57664-785; 61919-485; 51407-524; 80425-0135; 63629-1203; 50090-4842; 0615-8234; 12828-0060; 58118-0832; 46708-367; 61919-058; 55700-564; 46708-368; 57664-787; 48087-0038; 53002-7451; 51927-4663; 50090-2022; 71335-0022; 70518-2485; 71610-061; 67544-529; 45865-575; 71610-367; 62332-367; 63187-603; 62332-365; 49884-309; 70518-3144; 0004-0068; 68071-2310; 46708-366; 60687-544; 67544-288; 0093-9291; 72189-081; 71610-040; 50090-3467; 70518-1353; 49884-306; 50090-2088; 16729-137; 71335-0113; 68788-7738; 0093-3213; 70518-1801; 63629-8226; 71205-529; 43353-307; 43063-797; 71610-390; 61269-605; 60429-526; 63629-1202; 63187-888; 43547-406; 62332-366; 48087-0014; 63629-1205; 71610-085; 16729-138; 0395-8179; 68071-4021; 68071-5247; 55154-8125; 70518-2467; 0004-0098; 71610-363; 60429-524; 55700-830; 0228-3003; 63187-226; 0093-9294; 70518-2232; 49884-307; 0093-3212; 71610-039; 70518-1559; 61269-610; 43063-788; 71205-252; 71610-075; 67544-412; 71554-021; 0615-8236; 63629-1206; 70518-2507; 61269-620; 16729-136; 0093-9293; 71335-0333; 63629-1201; 63629-7649; 70518-2392; 63629-1116; 71335-1810; 71610-023; 71335-1856; 71610-368; 57664-783; 43547-407; 70518-2533; 64330-019; 57664-786; 50090-5399; 63629-1204; 0093-9292; 0093-0832; 46708-364; 67544-256; 46708-365; 17856-0835
Synonyms Clonazepam | 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro- | Rivotril | Klonopin | Antelepsin | Ro 5-4023 | Ro 54023
Chemical Information
Molecular Formula C15H10ClN3O3
CAS Registry Number 1622-61-3
SMILES C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.000194%Not Available
Abortion spontaneous18.01.04.001--Not Available
Accident12.01.08.001--Not Available
Acidosis14.01.03.0020.000194%
Acne23.02.01.001--Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000259%Not Available
Acute respiratory distress syndrome22.01.03.0010.000084%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000034%Not Available
Adams-Stokes syndrome17.02.04.010; 02.03.01.0010.000129%Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Aggression19.05.01.0010.001164%Not Available
Agitation19.06.02.001; 17.02.05.0120.001681%
Akathisia19.06.02.006; 17.01.02.0020.000129%
Akinesia17.01.02.003--Not Available
Alanine aminotransferase increased13.03.01.003--
Alcohol poisoning12.03.01.017--Not Available
Alcoholism19.07.02.0010.000129%Not Available
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000388%Not Available
Amnesia17.03.02.001; 19.20.01.0010.000259%
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anger19.04.02.0010.000453%Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anterograde amnesia17.03.02.005; 19.20.01.005--Not Available
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