Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Digoxin
Drug ID BADD_D00668
Description Digoxin is one of the oldest cardiovascular medications used today.[A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure.[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.[L9143] This drug originates from the foxglove plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.[A178240]
Indications and Usage For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
Marketing Status Prescription; Discontinued
ATC Code C01AA05
DrugBank ID DB00390
KEGG ID D00298
MeSH ID D004077
PubChem ID 2724385
TTD Drug ID D02OZE
NDC Product Code 71335-1540; 55154-5106; 69205-101; 0641-6184; 71335-1052; 0781-3059; 70515-260; 70518-1036; 63629-2579; 68071-3011; 70518-3124; 57664-437; 0115-9822; 63187-740; 16714-591; 59212-249; 42292-003; 70515-261; 0143-1241; 0404-9850; 50090-5311; 60687-551; 0054-0057; 60687-540; 50090-5276; 0641-1410; 63629-3870; 52584-410; 57664-441; 55154-5882; 69205-202; 0527-1324; 51662-1217; 51927-5045; 59695-0004; 0615-8202; 50090-5642; 69238-1991; 59212-242; 0378-6156; 59695-0001; 16714-590; 60429-100; 50090-4432; 69205-201; 0904-5921; 59695-0002; 0904-5922; 70954-201; 69292-605; 71052-275; 70515-263; 59651-436; 70515-262; 59212-240; 42292-002; 70518-2959; 59651-437; 0527-1325; 69238-1992; 70954-202; 42385-101; 0115-9811; 60429-099; 71610-019; 55742-123; 66689-327; 0143-1240; 0378-6155; 59651-438; 45085-0101; 50090-5862
Synonyms Digoxin | Lanacordin | Lanicor | Lanoxicaps | Dilanacin | Digacin | Digitek | Digoregen | Digoxina Boehringer | Boehringer, Digoxina | Digoxine Nativelle | Nativelle, Digoxine | Hemigoxine Nativelle | Nativelle, Hemigoxine | Mapluxin | Lanoxin | Lanoxin-PG | Lanoxin PG | Lenoxin
Chemical Information
Molecular Formula C41H64O14
CAS Registry Number 20830-75-5
SMILES CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O) OC8)O)C)O)C)C)C)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bone marrow failureATP-dependent translocase ABCB1P08183T2525810716719; 11356939; 12172213
Iron and trace metal metabolism disordersSodium/potassium-transporting ATPase subunit alpha-1P05023T4080011876554; 14602544; 12858216; 12856480
Iron and trace metal metabolism disorders3-hydroxy-3-methylglutaryl-coenzyme A reductaseP04035T5358511876554; 14602544; 12858216; 12856480
Mitochondrial toxicityCaspase-3P42574T5794311876554; 14602544; 12858216; 12856480
Mitochondrial toxicity3-hydroxy-3-methylglutaryl-coenzyme A reductaseP04035T5358511876554; 14602544; 12858216; 12856480
Tumour necrosisp21 proteinP78460Not Available11876554; 14602544; 12858216; 12856480
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.003394%
Abdominal pain upper07.01.05.003--
Acidosis14.01.03.0020.000636%
Activated partial thromboplastin time prolonged13.01.02.0010.000424%
Acute myocardial infarction24.04.04.001; 02.02.02.0010.001061%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000166%Not Available
Adams-Stokes syndrome02.03.01.001; 17.02.04.0100.000636%Not Available
Agitation19.06.02.001; 17.02.05.0120.001273%
Alanine aminotransferase increased13.03.01.0030.000636%
Altered state of consciousness17.02.04.001; 19.07.01.0030.000848%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.003182%
Anxiety19.06.02.002--
Aortic stenosis24.04.01.0010.000848%Not Available
Aortic valve incompetence02.07.03.0010.000424%Not Available
Apathy19.04.04.002--Not Available
Aphasia17.02.03.001; 19.21.01.0010.000424%
Arrhythmia02.03.02.0010.004242%Not Available
Arthralgia15.01.02.001--
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.001485%
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.006576%Not Available
Atrial fibrillation02.03.03.0020.007849%
Atrial flutter02.03.03.0030.001697%
Atrial tachycardia02.03.03.0040.001485%
Atrioventricular block02.03.01.0020.005303%Not Available
Atrioventricular block complete02.03.01.0030.004879%
Atrioventricular block first degree02.03.01.0040.003606%
Atrioventricular block second degree02.03.01.0050.002333%
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