Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hypertension
ADR ID BADD_A02149
ADR Hierarchy
24      Vascular disorders
24.08      Vascular hypertensive disorders
24.08.02      Vascular hypertensive disorders NEC
24.08.02.001      Hypertension
Description A disorder characterized by a pathological increase in blood pressure. [CTCAE] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]
MedDRA Code 10020772
MeSH ID D006973; D006973; D059466
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Blood pressure high | Blood pressure increased refractory | HBP | HT | Hypertension | Hypertension aggravated | Hypertension arterial | Hypertension complicating pregnancy, childbirth, and the puerperium | Hypertension exacerbated | Hypertension NOS | Hypertension not adequately controlled | Hypertension paroxysmal | Hypertension worsened | Hypertensive | Hypertensive episode | Hypertensive episodes | Increased BP slipping out of control | Other pre-existing hypertension complicating pregnancy, childbirth, and the puerperium | Other pre-existing hypertension complicating pregnancy, childbirth, and the puerperium, unspecified | Other pre-existing hypertension, antepartum | Other pre-existing hypertension, postpartum | Other pre-existing hypertension, with delivery | Other pre-existing hypertension, with delivery, with mention of postpartum complication | Refractory hypertension | Uncomplicated hypertension | Unspec hypertension comp preg,childbirth, or the puerperium, unspec as to eoc | Unspecified antepartum hypertension | Unspecified hypertension complicating pregnancy, childbirth, or the puerperium | Unspecified hypertension complicating pregnancy, childbirth, or the puerperium, unspecified as to ep | Unspecified hypertension, with delivery | Unspecified hypertension, with delivery, with mention of postpartum complication | Unspecified postpartum hypertension | White coat hypertension | Borderline hypertension | Uncontrolled hypertension | Blood Pressure, High | Blood Pressures, High | High Blood Pressure | High Blood Pressures
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Aquaporin-2P41181Not Available
Broad substrate specificity ATP-binding cassette transporter ABCG2Q9UNQ0T56556
Dihydropyrimidine dehydrogenase [NADP(+)]Q12882T75890
Endothelin-1P05305T25076
NeprilysinP08473T05409
Nitric oxide synthase, endothelialP29474T06046
Pro-thyrotropin-releasing hormoneP01150Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D000064r,6r-dorzolamide--
BADD_D00012Abatacept--
BADD_D00014Abiraterone--
BADD_D00015Abiraterone acetate--
BADD_D00016Acamprosate--
BADD_D00017Acamprosate calcium--
BADD_D00023Acetaminophen--
BADD_D00033Acetylsalicylic acid--
BADD_D00039Acyclovir--
BADD_D00041Adalimumab--
BADD_D00045Adenosine--
BADD_D00046Ado-trastuzumab emtansine--
BADD_D00047Afatinib--
BADD_D00048Aflibercept--
BADD_D00049Agalsidase beta--
BADD_D00054Albumin (human)--
BADD_D00056Albuterol--
BADD_D00057Albuterol sulfate--
BADD_D00062Aldesleukin--
BADD_D00064Alemtuzumab--
BADD_D00066Alendronic acid--
BADD_D00067Alfentanil--
BADD_D00068Alfentanil hydrochloride--
BADD_D00071Alglucosidase alfa--
BADD_D00073Aliskiren--
BADD_D00074Aliskiren hemifumarate--
BADD_D00076Allopurinol--
BADD_D00077Almotriptan--
BADD_D00078Almotriptan malate--
BADD_D00079Alogliptin--
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