Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Albuterol sulfate
Drug ID BADD_D00057
Description Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.[Label,A174379,A174400]
Indications and Usage Salbutamol is indicated for (i) the symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, reversible obstructive airway disease, and other chronic bronchopulmonary disorders in which bronchospasm is a complicating factor, and/or (ii) the acute prophylaxis against exercise-induced bronchospasm and other stimuli known to induce bronchospasm.[Label,F3265,F3268]
Marketing Status approved; vet_approved
ATC Code R03CC02; R03AC02
DrugBank ID DB01001
KEGG ID D00683
MeSH ID D000420
PubChem ID 39859
TTD Drug ID D0K5CB
NDC Product Code 75834-273; 76282-679; 43898-0123; 49452-0226; 69826-0003; 50090-0517; 50090-4138; 51407-367; 51407-368; 51662-1267; 65862-858; 0487-9901; 70518-3442; 71205-441; 0591-3468; 75834-274; 51927-0151; 55545-0410; 50090-4137; 50383-740; 59651-183; 65302-064; 0378-7058; 70752-102; 0591-3467; 76204-010; 53104-7506; 50090-5231; 51662-1513; 53002-1750; 53002-2584; 55154-4359; 70518-1237; 0054-0742; 55154-4350; 59310-540; 59310-579; 68788-8399; 70518-2613; 70518-3541; 71205-211; 76420-087; 0781-7296; 12828-0063; 51662-1499; 53002-1552; 62135-189; 62135-672; 63187-026; 66993-019; 68071-1890; 68071-2300; 68084-952; 0487-9501; 69826-0002; 45802-088; 47335-703; 0378-8270; 68071-1670; 68788-7702; 76420-531; 51927-1573; 0093-3174; 53489-177; 59310-580; 59651-184; 60687-395; 68071-5206; 80425-0266; 11517-012; 43898-0133; 53002-1554; 55700-908; 65302-060; 65302-061; 65302-065; 0378-7057; 68071-2679; 70518-3560; 71872-7054; 76204-011; 76420-088; 48292-0012; 50383-741; 59310-117; 62135-671; 0378-6991; 0378-6992; 66758-959; 68084-949; 68788-7996; 0472-0825; 0487-0301; 0487-9904; 71205-641; 71205-732; 72572-014; 76204-200; 61281-3700; 0173-0682; 50090-1159; 53489-176; 55154-2132; 60687-662; 63187-204; 68071-2656; 68180-963; 68788-7573; 69097-142; 70518-1081; 58032-0002; 50090-0516; 50090-6560; 55154-4410
UNII 021SEF3731
Synonyms Albuterol | Salbutamol | 2-t-Butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol | Ventolin | Sultanol | Albuterol Sulfate | Proventil
Chemical Information
Molecular Formula C26H44N2O10S
CAS Registry Number 51022-70-9
SMILES CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.OS(=O)(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009--Not Available
Cough22.02.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Dry throat22.12.03.005; 07.06.01.005--Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Dysuria20.02.02.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hypertension24.08.02.001--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Malaise08.01.01.003--
Muscle spasms15.05.03.004--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Oropharyngeal swelling23.04.01.013; 22.04.05.005; 10.01.05.014; 07.05.04.002--Not Available
Palpitations02.11.04.012--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Somnolence19.02.05.003; 17.02.04.006--
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