Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abatacept
Drug ID BADD_D00012
Description Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. It is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. Although approved for the treatment of rheumatoid arthritis, Repligen has entered a slightly different formulation of CTLA4-Ig into clinical trials (RG2077).
Indications and Usage For the management of the signs and symptoms of moderate-to-severe active rheumatoid arthritis, inducing major clinical response, slowing the progression of structural damage, and improving physical function in adult patients. It is indicated both as a monotherapy and for use in combination with a continued regimen of DMARDs (not including TNF antagonists). Also used for the management of the signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in children.
Marketing Status Prescription
ATC Code L04AA24
DrugBank ID DB01281
KEGG ID D03203
MeSH ID D000069594
PubChem ID Not Available
NDC Product Code 0003-2814; 0003-2818; 0003-2188; 70409-2187; 0003-2187
Synonyms Abatacept | CTLA-4-Ig | Cytotoxic T Lymphocyte-Associated Antigen 4-Immunoglobulin | Cytotoxic T Lymphocyte Associated Antigen 4 Immunoglobulin | CTLA4-Ig | CTLA4-Ig Immunoconjugate | CTLA4 Ig Immunoconjugate | Immunoconjugate, CTLA4-Ig | CTLA4-Fc | BMS224818 | BMS-224818 | BMS 224818 | Belatacept | Orencia | BMS 188667 | BMS-188667 | BMS188667 | LEA29Y | Nulojix
Chemical Information
Molecular Formula Not Available
CAS Registry Number 332348-12-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Back pain15.03.04.005--
Cellulitis23.09.01.001; Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Diverticulitis11.01.07.003; Available
Herpes simplex23.09.03.001; Available
Herpes zoster11.05.02.003;
Infection11.01.08.002--Not Available
Influenza22.07.02.001; Available
Localised infection11.01.08.006--Not Available
Nasopharyngitis11.01.13.002; Available
Neoplasm malignant16.16.01.001--Not Available
Pain in extremity15.03.04.010--
Pneumonia22.07.01.003; Available
Pyelonephritis acute20.01.09.002; Available
Rash23.03.13.001--Not Available
Rhonchi22.02.04.005--Not Available
Upper respiratory tract infection22.07.03.011;
Urinary tract infection11.01.14.004;
The 1th Page    1 2    Next   Last    Total 2 Pages