Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Renal failure
ADR ID BADD_A03749
ADR Hierarchy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.005      Renal failure
Description Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE. | A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. [MeSH]
MedDRA Code 10038435
MeSH ID D051437; D051437; D051437
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Failure kidney | Insufficiency renal | Kidney failure | Progressive renal failure | Renal failure | Renal failure aggravated | Renal failure following abortion and ectopic and molar pregnancies | Renal failure NOS | Renal failure unspecified | Renal failure, unspecified | Renal insufficiency | Renal insufficiency aggravated | Anuric renal failure | Renal Insufficiency | Renal Insufficiencies | Kidney Insufficiency | Insufficiency, Kidney | Kidney Insufficiencies | Kidney Failure | Failure, Kidney | Failures, Kidney | Kidney Failures | Renal Failure | Failure, Renal | Failures, Renal | Renal Failures
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Lipoprotein lipaseP06858T28692
Very low-density lipoprotein receptorP98155Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D000042-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate--
BADD_D00008Abacavir0.004928%
BADD_D00009Abacavir succinate--
BADD_D00014Abiraterone--
BADD_D00023Acetaminophen0.000227%
BADD_D00028Acetohydroxamic acid--
BADD_D00033Acetylsalicylic acid0.000024%
BADD_D00039Acyclovir0.000204%
BADD_D00040Acyclovir sodium--
BADD_D00043Adefovir--
BADD_D00044Adefovir dipivoxil0.001510%
BADD_D00047Afatinib0.001390%
BADD_D00049Agalsidase beta--
BADD_D00062Aldesleukin--
BADD_D00066Alendronic acid0.000764%
BADD_D00073Aliskiren0.003643%
BADD_D00076Allopurinol0.000860%
BADD_D00085Alprazolam--
BADD_D00086Alprostadil--
BADD_D00100Ambrisentan0.005573%
BADD_D00102Amifostine--
BADD_D00106Aminocaproic acid--
BADD_D00115Amiodarone0.001553%
BADD_D00116Amiodarone hydrochloride--
BADD_D00121Amlodipine--
BADD_D00129Amoxicillin--
BADD_D00132Amphotericin b0.000645%
BADD_D00137Amsacrine--
BADD_D00139Anagrelide0.000208%
BADD_D00140Anagrelide hydrochloride--
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