Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amsacrine
Drug ID BADD_D00137
Description Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Indications and Usage For treatment of acute myeloid leukaemia.
Marketing Status Not Available
ATC Code L01XX01
DrugBank ID DB00276
KEGG ID D02321
MeSH ID D000677
PubChem ID 2179
NDC Product Code Not Available
Synonyms Amsacrine | Cain's Acridine | Cain Acridine | Cains Acridine | meta-AMSA | meta AMSA | AMSA | m-AMSA | Amsidyl | SN-11841 | SN 11841 | SN11841 | NSC-156303 | NSC 156303 | NSC156303 | NSC-249992 | NSC 249992 | NSC249992 | Amsidine | Amsacrina | AMSA P-D | AMSA P D | AMSA PD | NSC-141549 | NSC 141549 | NSC141549
Chemical Information
Molecular Formula C21H19N3O3S
CAS Registry Number 51264-14-3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cytogenetic investigationsDNA topoisomerase 1P11387T098261997159; 1649059; 1333822; 1540962; 1596908; 1330289; 8382551; 2168279; 2168281; 1319346; 11062742; 1374671; 1646393; 7882360; 1322239; 7688316; 1659821; 8383887; 8144400; 1698546
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Aplasia08.03.04.003; Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.002--
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiomyopathy02.04.01.001--Not Available
Confusional state19.13.01.001;
Dermatitis23.03.04.002--Not Available
Extravasation08.01.03.008--Not Available
Febrile neutropenia08.05.02.004;
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
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