Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Adefovir dipivoxil
Drug ID BADD_D00044
Description Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
Indications and Usage For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Marketing Status Prescription
ATC Code J05AF08
DrugBank ID DB00718
KEGG ID D01655
MeSH ID C106812
PubChem ID 60871
TTD Drug ID D0ML1F
NDC Product Code 60505-3947; 53104-7602; 61958-0501; 42794-003; 65977-0051
Synonyms adefovir dipivoxil | adefovir depivoxil | 9-(2-((-bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine | Hepsera | Preveon | GS 840 | GS-0840
Chemical Information
Molecular Formula C20H32N5O8P
CAS Registry Number 142340-99-6
SMILES CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.002170%
Abdominal pain07.01.05.002--
Acidosis14.01.03.0020.001447%
Acidosis hyperchloraemic14.01.01.0070.001447%Not Available
Alanine aminotransferase increased13.03.01.0030.006510%
Albumin urine present13.13.02.0120.001447%Not Available
Alopecia23.02.02.001--
Aminoaciduria14.14.04.003; 03.08.04.003; 20.02.01.0240.005787%Not Available
Anaemia01.03.02.001--
Ankle fracture15.08.03.005; 12.04.01.0050.002893%
Arthralgia15.01.02.0010.049909%
Arthritis15.01.01.0010.001447%
Aspartate aminotransferase increased13.03.01.0060.004340%
Asthenia08.01.01.0010.013743%Not Available
Autonomic nervous system imbalance08.01.01.010; 24.06.01.005; 17.05.01.0110.001447%Not Available
Back pain15.03.04.0050.029656%
Beta 2 microglobulin urine increased13.09.01.0160.002170%Not Available
Blood albumin decreased13.09.01.0010.001447%Not Available
Blood bilirubin increased13.03.01.0080.002893%
Blood calcium decreased13.11.01.0020.005063%Not Available
Blood creatine phosphokinase increased13.04.01.0010.007233%
Blood creatinine increased13.13.01.0040.022423%
Blood glucose increased13.02.02.0020.002170%Not Available
Blood potassium decreased13.11.01.0100.009403%Not Available
Blood potassium increased13.11.01.0110.001447%Not Available
Blood pressure decreased13.14.03.0020.001447%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood thyroid stimulating hormone increased13.10.03.0060.001447%
Blood uric acid decreased13.02.04.0040.005787%Not Available
Blood uric acid increased13.02.04.0010.004340%Not Available
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