Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hepatotoxicity
ADR ID BADD_A02053
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.009      Hepatotoxicity
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.008      Hepatotoxicity
Description Not Available
MedDRA Code 10019851
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Hepatotoxic effect | Hepatotoxicity | Hepatotoxicity aggravated | Hepatotoxicity NOS | Toxaemia of liver | Toxemia of liver | Toxic acute liver disease
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Alanine aminotransferase 1P24298Not Available
Alanine aminotransferase 1Q8QZR5Not Available
AlbuminP02768T63068
AlbuminP02770Not Available
Alkaline phosphatase, placental typeP05187Not Available
Alkaline phosphatase, tissue-nonspecific isozymeP05186T09538
Alpha-fetoproteinP02771T10828
Aspartate aminotransferase, mitochondrialP05202Not Available
ATP-binding cassette subfamily B member 1AQ9JK64Not Available
Beta-2 adrenergic receptorP07550T52522
Caspase recruitment domain-containing protein 10Q9BWT7Not Available
CatalaseP04762Not Available
CholinesteraseP06276T99799
Cytochrome P450Q14097Not Available
Cytochrome P450 1A1P04798Not Available
Cytochrome P450 1A2P05177Not Available
Cytochrome P450 2A6P11509T06455
Cytochrome P450 2C19P33261Not Available
Cytochrome P450 2C9P11712T19244
Cytochrome P450 2D6P10635T57392
Cytochrome P450 2E1P05181Not Available
Cytochrome P450 2E1Q05421Not Available
Cytochrome P450 3A4P08684T37848
Diazepam-binding inhibitor-like 5P56702Not Available
Fibroblast growth factor 4P08620T28076
Glucocorticoid receptorP04150T40016
Glutathione peroxidase 1P04041Not Available
L-lactate dehydrogenase A chainP00338T15053
Metallothionein-1AP04731Not Available
MyeloperoxidaseP05164T23471
MyeloperoxidaseP11247Not Available
N-alpha-acetyltransferase 20P61599Not Available
Nitric oxide synthase, inducibleQ06518Not Available
Omega-amidase NIT2Q9JHW2Not Available
Ornithine decarboxylaseP11926T60366
Solute carrier family 12 member 3P55017T84886
Sorbitol dehydrogenaseQ00796T59445
Superoxide dismutase [Cu-Zn]P07632Not Available
Transcription factor JunP05412T69085
Transforming protein v-Fos/v-FoxP29176Not Available
Tumor necrosis factorP06804Not Available
Tumor necrosis factorP16599Not Available
Tyrosine aminotransferaseP17735Not Available
UDP-glucuronosyltransferase 1-6P19224Not Available
UDP-glucuronosyltransferase 1A1P22309T93480
UDP-glucuronosyltransferase 1A9O60656Not Available
UDP-glucuronosyltransferase 2B15P54855Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone--
BADD_D00023Acetaminophen--
BADD_D00032Acetylcysteine--
BADD_D00033Acetylsalicylic acid--
BADD_D00047Afatinib--
BADD_D00076Allopurinol--
BADD_D00085Alprazolam--
BADD_D00088Altretamine--
BADD_D00100Ambrisentan--
BADD_D00106Aminocaproic acid--
BADD_D00107Aminoglutethimide--
BADD_D00115Amiodarone--
BADD_D00129Amoxicillin--
BADD_D00130Amphetamine--
BADD_D00132Amphotericin b--
BADD_D00137Amsacrine--
BADD_D00139Anagrelide--
BADD_D00140Anagrelide hydrochloride--
BADD_D00142Anastrozole--
BADD_D00165Aripiprazole--
BADD_D00169Arsenic trioxide--
BADD_D00175Asparaginase--
BADD_D00178Atenolol--
BADD_D00180Atomoxetine--
BADD_D00193Axitinib--
BADD_D00194Azacitidine--
BADD_D00195Azathioprine--
BADD_D00196Azathioprine sodium--
BADD_D00203Azithromycin--
BADD_D00210Balsalazide--
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