Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetylcysteine
Drug ID BADD_D00032
Description Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.[L31488]
Indications and Usage Acetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
Marketing Status Prescription; Discontinued
ATC Code R05CB01; S01XA08; V03AB23
DrugBank ID DB06151
KEGG ID D00221
MeSH ID D000111
PubChem ID 12035
TTD Drug ID D06XGW
NDC Product Code 12598-7327; 55154-5730; 52932-0704; 55154-5731; 70710-1015; 51927-1601; 12598-7308; 63323-695; 63323-694; 0517-7610; 66220-207; 12598-7302; 51552-0201; 38779-0495; 12598-7027; 63323-963; 12598-7311; 55150-259; 0409-3307; 63323-690; 0409-3308; 0517-7604; 63323-693; 52932-0742; 63323-692; 25021-812; 0517-7630; 0517-7510; 38779-2700; 63323-691; 17478-660; 52133-0002; 49452-0098; 12598-7323; 14445-412; 70771-1412; 12598-7294; 0517-7504; 10695-066; 0574-0805
Synonyms Acetylcysteine | N-Acetyl-L-cysteine | N Acetyl L cysteine | N-Acetylcysteine | N Acetylcysteine | Mercapturic Acid | Acid, Mercapturic | Solmucol | Genac | Acemuc | Acetabs | Acetylcystein AL | NAC AL | Acetylcystein Atid | Acetylcystein Heumann | Acetylcystein Trom | Acetylcysteine Hydrochloride | Hydrochloride, Acetylcysteine | Acetylcysteine Sodium | Sodium, Acetylcysteine | Acetylcysteine, Monosodium Salt | Monosodium Salt Acetylcysteine | Acetylcysteine Zinc | Zinc, Acetylcysteine | Acetylcysteine, (D)-Isomer | Acetylcysteine, (DL)-Isomer | Acetylcysteine, Monoammonium Salt | Monoammonium Salt Acetylcysteine | Acetyst | Acétylcystéine GNR | Airbron | Alveolex | Bromuc | Azubronchin | Bisolvon NAC | NAC, Bisolvon | Broncho-Fips | Broncho Fips | BronchoFips | Broncholysin | Broncoclar | Codotussyl | Cystamucil | Dampo Mucopect | Mucopect, Dampo | durabronchal | Larylin NAC | Eurespiran | Exomuc | Fluimucil | NAC Zambon | Zambon, NAC | Fabrol | Fluprowit | Optipect Hustengetränk | Hustengetränk, Optipect | Muco Sanigen | Sanigen, Muco | Frekatuss | Jenacystein | Jenapharm | Lantamed | Lindocetyl | M-Pectil | M Pectil | MPectil | mentopin Acetylcystein | Acetylcystein, mentopin | Muciteran | Mucomyst | Acetylin | Mucosil | Mucosol | Mucosolvin | Siccoral | Siran | Ilube | Hoestil | acebraus
Chemical Information
Molecular Formula C5H9NO3S
CAS Registry Number 616-91-1
SMILES CC(=O)NC(CS)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Hepatic function abnormalG2/mitotic-specific cyclin-B2P30276Not Available25744598
Hepatic function abnormalCyclin-A1Q61456Not Available25744598
Hepatic function abnormalG1/S-specific cyclin-D1P25322Not Available25744598
Hepatic function abnormalCyclin-FP51944Not Available25744598
Hepatic function abnormalG2/mitotic-specific cyclin-B1P24860Not Available25744598
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.0010.000169%Not Available
Agitation19.06.02.001; 17.02.05.0120.001616%
Alanine aminotransferase increased13.03.01.0030.000969%
Amnesia19.20.01.001; 17.03.02.0010.000646%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.003231%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000506%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.002908%Not Available
Angioedema23.04.01.001; 10.01.05.0090.001616%Not Available
Asthma22.03.01.002; 10.01.03.0100.000646%Not Available
Blister23.03.01.001; 12.01.06.0020.000646%Not Available
Body temperature increased13.15.01.001--Not Available
Brain herniation12.01.10.001; 17.11.01.0020.000169%Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.001292%
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000969%Not Available
Coagulopathy01.01.02.0010.000169%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Compartment syndrome24.04.05.006; 15.05.05.0050.001292%Not Available
Cough22.02.03.0010.000646%
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.000646%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.001292%
Drug abuse19.07.02.0100.000646%Not Available
Drug dependence19.07.02.0090.000969%Not Available
Drug hypersensitivity10.01.01.0010.000969%Not Available
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.000646%
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.0020.003554%
Ear disorder04.03.01.001--Not Available
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