Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.[L11214]
Marketing Status approved
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 62991-2189; 65649-231; 67877-492; 68084-229; 68382-120; 51407-182; 68382-118; 72789-129; 46014-1110; 70771-1141; 60219-1076; 60219-2036; 60219-2037; 68382-003; 48954-909; 51927-0071; 68682-241; 70518-3544; 70771-1140; 51927-2258; 54766-590; 65841-602; 12780-0300; 38779-0312; 66122-0009; 42291-063; 68462-502; 71610-124; 42291-071; 68682-231; 70771-1139; 15308-0732; 49452-0783; 67877-493; 51552-0779; 65649-241; 67877-494; 67877-495; 68382-119; 42973-143
UNII MRK240IY2L
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal adhesions12.02.03.006; 07.07.03.0010.002663%Not Available
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.004292%
Abdominal pain07.01.05.0020.022715%
Abdominal pain lower07.01.05.0100.001097%Not Available
Abdominal pain upper07.01.05.0030.004700%
Abdominal tenderness07.01.05.0040.000313%Not Available
Abnormal faeces07.01.03.001--Not Available
Abortion spontaneous18.01.04.0010.003446%Not Available
Acidosis14.01.03.0020.000313%
Acne23.02.01.0010.000627%Not Available
Actinic keratosis23.01.06.0010.000783%Not Available
Acute abdomen07.01.06.0150.000313%Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.002976%Not Available
Acute hepatic failure09.01.03.0010.000627%Not Available
Acute leukaemia16.01.02.001; 01.10.02.0010.000313%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000783%Not Available
Acute promyelocytic leukaemia16.01.05.003; 01.10.05.0030.000470%Not Available
Acute respiratory distress syndrome24.03.02.034; 10.02.01.067; 22.01.03.0010.002506%
Agranulocytosis01.02.03.0010.000783%Not Available
Air embolism24.01.01.001; 12.02.05.0080.000313%Not Available
Alopecia23.02.02.0010.007801%
Anaemia01.03.02.0010.008365%
Anaemia macrocytic14.12.01.002; 01.03.02.0020.000470%Not Available
Anaemia megaloblastic14.12.01.003; 01.03.02.003--Not Available
Anal fissure07.03.01.0020.000783%
Anal fistula07.11.05.0020.005546%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.002412%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000627%Not Available
Aneurysm24.02.01.0010.000313%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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