Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Anstey A, Lear JT: Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs. 1998 Jan;9(1):33-47.
Marketing Status Prescription; Discontinued
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 72789-129; 51407-182; 46014-1110; 62991-2189; 12780-0300; 51927-2258; 48954-909; 51552-0779; 15308-0732; 42973-143; 68382-120; 38779-0312; 68382-119; 67877-492; 70771-1139; 65649-241; 68382-118; 67877-494; 54766-590; 68462-502; 0378-1005; 71610-124; 60219-2036; 70771-1140; 51927-0071; 65841-602; 68382-003; 71610-306; 42291-071; 60219-2037; 68084-229; 60219-1076; 70771-1141; 49452-0783; 65649-231; 67877-495; 67877-493; 66122-0009
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionInosine triphosphate pyrophosphataseQ9BY32Not Available15167706; 15571265; 15973722
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityCytosolic 5'-nucleotidase 1AQ9BXI3Not Available7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityPurine nucleoside phosphorylaseP00491T781987818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal adhesions12.02.03.006; 07.07.03.0010.012206%Not Available
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.017232%
Abdominal pain07.01.05.0020.076108%
Abdominal pain lower07.01.05.0100.005026%Not Available
Abdominal pain upper07.01.05.0030.017232%
Abdominal tenderness07.01.05.0040.002154%Not Available
Abdominal wall abscess11.01.07.018; 07.19.02.0090.001436%Not Available
Abortion spontaneous18.01.04.0010.010052%Not Available
Abscess11.01.08.0010.011488%Not Available
Acne23.02.01.0010.002872%Not Available
Actinic keratosis23.01.06.0010.002154%Not Available
Acute abdomen07.01.06.0150.000375%Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.009334%Not Available
Acute hepatic failure09.01.03.0010.000749%Not Available
Acute leukaemia16.01.02.001; 01.10.02.0010.000375%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.001311%Not Available
Acute promyelocytic leukaemia16.01.05.003; 01.10.05.0030.003590%Not Available
Acute respiratory distress syndrome22.01.03.0010.002248%
Agranulocytosis01.02.03.001--Not Available
Air embolism24.01.01.001; 12.02.05.0080.001436%Not Available
Alanine aminotransferase increased13.03.01.0030.008616%
Alopecia23.02.02.0010.013642%
Amylase increased13.05.01.0090.001436%
Anaemia01.03.02.0010.033028%
Anaemia macrocytic14.12.01.002; 01.03.02.0020.002154%Not Available
Anaemia megaloblastic01.03.02.003; 14.12.01.003--Not Available
Anal fissure07.03.01.0020.002154%
Anal fistula07.11.05.0020.020822%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.005744%
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