Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine sodium
Drug ID BADD_D00196
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Anstey A, Lear JT: Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs. 1998 Jan;9(1):33-47.
Marketing Status Prescription; Discontinued
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D03033
MeSH ID D001379
PubChem ID 11529527
NDC Product Code 0143-9566
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H6N7NaO2S
CAS Registry Number 55774-33-9
SMILES CN1C=NC(=C1SC2=NC=NC3=C2N=C[N-]3)[N+](=O)[O-].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionInosine triphosphate pyrophosphataseQ9BY32Not AvailableNot Available
Adverse drug reactionThiopurine S-methyltransferaseP51580Not AvailableNot Available
Bone marrow toxicityCytosolic 5'-nucleotidase 1AQ9BXI3Not AvailableNot Available
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not AvailableNot Available
Bone marrow toxicityPurine nucleoside phosphorylaseP00491T78198Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute febrile neutrophilic dermatosis23.03.03.033; Available
Anaemia macrocytic14.12.01.002; Available
Blood bilirubin13.03.01.040--Not Available
Hepatotoxicity12.03.01.008; Available
Infection11.01.08.002--Not Available
Interstitial lung disease22.01.02.003; Available
Leukopenia01.02.02.001--Not Available
Lymphoma16.20.01.001; Available
Neoplasm16.16.02.001--Not Available
Nitrogen balance negative13.13.01.010--Not Available
Rash23.03.13.001--Not Available
Rheumatoid arthritis15.01.03.001; Available
Steatorrhoea07.17.01.002--Not Available
Transaminases13.03.01.045--Not Available
Haemorrhage24.07.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Bone marrow failure01.03.03.005--
Hepatosplenic T-cell lymphoma16.17.01.001; Available
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