Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cardiomegaly
ADR ID BADD_A00795
ADR Hierarchy
02      Cardiac disorders
02.04      Myocardial disorders
02.04.02      Myocardial disorders NEC
02.04.02.001      Cardiomegaly
Description Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. | Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. [MeSH]
MedDRA Code 10007632
MeSH ID D006332
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cardiac dilatation | Cardiomegaly | Cardiomegaly (excl hypertensive) | Cardiomegaly NOS | Enlargement heart | Heart enlarged | Megalocardia | Heart Enlargement | Enlargement, Heart | Enlarged Heart | Heart, Enlarged | Cardiac Hypertrophy | Heart Hypertrophy
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00056Albuterol0.000006%
BADD_D00066Alendronic acid0.000704%
BADD_D00073Aliskiren0.000609%
BADD_D00085Alprazolam--
BADD_D00100Ambrisentan0.000975%
BADD_D00115Amiodarone0.001037%
BADD_D00129Amoxicillin0.000007%
BADD_D00132Amphotericin b--
BADD_D00139Anagrelide--
BADD_D00165Aripiprazole--
BADD_D00178Atenolol--
BADD_D00190Atropine sulfate--
BADD_D00203Azithromycin0.000009%
BADD_D00260Betamethasone--
BADD_D00271Bicalutamide0.002109%
BADD_D00285Bosentan0.000481%
BADD_D00286Bosutinib0.000224%
BADD_D00304Bromocriptine0.001319%
BADD_D00312Bupropion0.000018%
BADD_D00318Busulfan--
BADD_D00329Cabergoline0.007207%
BADD_D00356Carbamazepine0.000465%
BADD_D00367Carfilzomib0.000392%
BADD_D00410Celecoxib0.000075%
BADD_D00414Ceritinib0.000168%
BADD_D00424Cevimeline--
BADD_D00425Cevimeline hydrochloride--
BADD_D00440Chloroquine0.000142%
BADD_D00474Cisplatin0.000168%
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