Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Busulfan
Drug ID BADD_D00318
Description Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Indications and Usage For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases.
Marketing Status Prescription
ATC Code L01AB01
DrugBank ID DB01008
KEGG ID D00248
MeSH ID D002066
PubChem ID 2478
NDC Product Code 46014-1116; 72485-210; 50683-0363; 60505-6177; 71288-158; 51817-170; 48957-0010; 65219-160; 14096-147; 29902-0007; 67457-893; 0409-1112; 76388-713; 46439-8734; 0517-0920; 70121-1244; 59148-070; 72606-559; 25021-241; 69443-500; 16729-351; 63759-0008; 71288-116
Synonyms Busulfan | Busulphan | Busulfan Wellcome | Wellcome, Busulfan | Busulfex | Myleran | Myléran | Myelosan | Mylecytan | n-Butane-1,3-di(methylsulfonate) | Glyzophrol
Chemical Information
Molecular Formula C6H14O6S2
CAS Registry Number 55-98-1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Acute leukaemia16.01.02.001; Available
Acute myeloid leukaemia16.01.05.001; Available
Acute respiratory distress syndrome22.01.03.0010.000417%
Acute respiratory failure22.02.06.001; Available
Addison's disease05.01.02.006;; Available
Adrenal insufficiency14.11.01.004;
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.0030.000533%
Anhidrosis23.02.03.001--Not Available
Anorectal disorder07.03.01.001--Not Available
Aplasia03.02.01.002; Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Aspartate aminotransferase increased13.03.01.0060.000533%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.002--
Atrioventricular block complete02.03.01.003--
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