Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bicalutamide
Drug ID BADD_D00271
Description Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Indications and Usage For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Marketing Status Prescription; Discontinued
ATC Code L02BB03
DrugBank ID DB01128
KEGG ID D00961
MeSH ID C053541
PubChem ID 2375
TTD Drug ID D0V9BD
NDC Product Code 60429-177; 70518-2993; 51846-1028; 16714-816; 62559-680; 0904-6019; 16729-023; 43265-0705; 15308-0360; 54893-0001; 49711-1504; 65841-613; 43265-7195; 49711-1509; 71205-577; 68382-224; 47335-485; 63629-8308; 63759-0004; 62559-890; 53104-7664; 46014-1111; 58623-0068
Synonyms bicalutamide | 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide | Casodex | Cosudex | ICI-176334 | ICI 176334
Chemical Information
Molecular Formula C18H14F4N2O4S
CAS Registry Number 90357-06-5
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.045111%
Abdominal pain upper07.01.05.003--
Abscess11.01.08.0010.006444%Not Available
Acute hepatic failure09.01.03.0010.005043%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.001681%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.029000%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.001681%Not Available
Acute respiratory distress syndrome22.01.03.0010.002522%
Acute respiratory failure14.01.04.004; 22.02.06.0010.003362%Not Available
Affective disorder19.04.04.0010.012889%Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.01.0030.041889%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.009667%Not Available
Anaemia01.03.02.0010.087000%
Anaesthesia17.02.07.0020.003362%Not Available
Anal fistula07.11.05.0020.006444%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.012889%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angina unstable24.04.04.004; 02.02.02.0040.006444%Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anorectal disorder07.03.01.001--Not Available
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.0010.006444%Not Available
Aphasia17.02.03.001; 19.21.01.0010.009667%
Aphthous ulcer07.05.06.0020.006444%Not Available
Aplastic anaemia01.03.03.0020.001681%Not Available
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