Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Torsade de pointes
ADR ID BADD_A04352
ADR Hierarchy
02      Cardiac disorders
02.03      Cardiac arrhythmias
02.03.04      Ventricular arrhythmias and cardiac arrest
02.03.04.005      Torsade de pointes
Description A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION. [MeSH]
MedDRA Code 10044066
MeSH ID D016171; D016171; D016171
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Torsade de pointes | Torsades de pointes | TdP ventricular tachycardia | Helicoidal ventricular tachycardia | Torsades de Pointes | Pointes, Torsades de | de Pointes, Torsades | Torsade de Pointes | Pointes, Torsade de | de Pointes, Torsade
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Misshapen-like kinase 1Q8N4C8Not Available
Potassium voltage-gated channel subfamily H member 2Q12809T20251
Potassium voltage-gated channel subfamily KQT member 1P51787T49526
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00045Adenosine--
BADD_D00069Alfuzosin--
BADD_D00076Allopurinol--
BADD_D00085Alprazolam--
BADD_D00115Amiodarone--
BADD_D00117Amisulpride--
BADD_D00118Amitriptyline--
BADD_D00139Anagrelide--
BADD_D00165Aripiprazole--
BADD_D00168Arsenic--
BADD_D00176Atazanavir--
BADD_D00203Azithromycin--
BADD_D00205Azithromycin monohydrate--
BADD_D00221Bedaquiline--
BADD_D00254Bepridil--
BADD_D00271Bicalutamide--
BADD_D00277Bisoprolol--
BADD_D00284Bortezomib--
BADD_D00310Buprenorphine--
BADD_D00312Bupropion--
BADD_D00349Capecitabine--
BADD_D00356Carbamazepine--
BADD_D00390Cefotaxime--
BADD_D00405Ceftriaxone--
BADD_D00417Cetirizine--
BADD_D00466Cilostazol--
BADD_D00467Cimetidine--
BADD_D00471Ciprofloxacin--
BADD_D00472Ciprofloxacin hydrochloride--
BADD_D00475Citalopram--
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