Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cilostazol
Drug ID BADD_D00466
Description Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reducing calcium-induced contractions.
Indications and Usage For the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
Marketing Status Prescription; Discontinued
ATC Code B01AC23
DrugBank ID DB01166
KEGG ID D01896
MeSH ID D000077407
PubChem ID 2754
NDC Product Code 46438-0632; 70518-2208; 72189-116; 66039-113; 0185-0223; 71610-037; 0093-2064; 0093-2065; 60505-2521; 70518-2714; 46438-0633; 50090-5329; 0054-0028; 50268-177; 70436-157; 63629-8796; 70518-2200; 0054-0044; 50268-176; 42291-453; 58175-0379; 70436-156; 63629-8795; 67680-001; 60505-2522; 42185-7038; 63415-0034; 46438-1109
Synonyms Cilostazol | 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone | OPC 13013 | OPC-13013 | Pletal
Chemical Information
Molecular Formula C20H27N5O2
CAS Registry Number 73963-72-1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal faeces07.01.03.001--Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.001375%
Acute myocardial infarction24.04.04.001; Available
Agranulocytosis01.02.03.001--Not Available
Albuminuria20.02.01.001--Not Available
Amblyopia06.02.01.001--Not Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Aplastic anaemia01.03.03.002--Not Available
Arteriovenous fistula24.03.03.0010.001375%Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.0020.002751%
Atrial flutter02.03.03.003--
Atrioventricular block complete02.03.01.003--
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
Blindness17.17.01.003; Available
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood pressure decreased13.14.03.0020.000718%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
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