Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ciprofloxacin
Drug ID BADD_D00471
Description Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics.[A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.[L6463]
Indications and Usage For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
Marketing Status Prescription; Discontinued
ATC Code J01MA02; S01AE03; S02AA15; S03AA07
DrugBank ID DB00537
KEGG ID D00186
MeSH ID D002939
PubChem ID 2764
TTD Drug ID D0O1WX
NDC Product Code 68071-4260; 70934-934; 50090-4769; 68071-4387; 70985-008; 0615-8147; 35356-733; 61919-795; 66267-716; 45865-772; 63187-142; 60429-042; 67296-0237; 16571-411; 43063-767; 0143-9928; 72789-193; 76420-214; 53002-2791; 61919-361; 68071-2404; 72789-125; 70518-3063; 50419-773; 70518-0010; 16571-412; 0409-4777; 71335-1640; 66992-450; 53002-7320; 60760-676; 70518-0368; 61919-371; 68071-2510; 72789-124; 68071-2525; 71335-1393; 63187-990; 54348-662; 55700-737; 45865-994; 0904-7083; 70985-012; 0904-6378; 36000-298; 70934-316; 36000-009; 67296-1269; 71205-300; 42195-550; 43063-410; 55154-7283; 63629-7786; 67296-1097; 72189-242; 68788-7500; 67296-0853; 68071-4672; 50090-4217; 16571-413; 50090-5483; 0143-9927; 16252-516; 50090-4220; 67296-1389; 53069-0680; 50090-1648; 68788-9012; 50090-3573; 58032-0127; 55111-125; 50419-777; 53002-2640; 68071-2383; 63629-5154; 63187-001; 72789-108; 72189-323; 72189-304; 71610-081; 60760-815; 68788-9006; 68788-7857; 58657-676; 43063-869; 71335-2054; 80425-0164; 63187-017; 63629-7950; 68788-9280; 70934-790; 52286-0014; 42708-146; 25021-114; 70518-3035; 16252-515; 67296-1575; 68788-8088; 68071-2335; 50090-5382; 68071-4679; 67296-1318; 55111-126; 55111-015; 0615-8367; 72789-118; 68071-4201; 70518-0693; 68071-2438; 68788-9024; 16252-514; 55111-127; 55154-3368; 36000-008; 69315-308; 50090-5621; 12527-0540; 42708-002; 68071-1893; 54348-663; 70518-1090; 12527-0537; 63629-3868; 68071-2384; 55111-128; 43063-547; 50090-1685; 42708-088; 72189-300; 45865-471; 58032-2027; 70518-2837; 50090-5505; 70985-011; 70518-2390; 68071-2374; 43063-427; 71335-1867; 53002-2790; 50090-5624; 68788-7905; 50090-1649; 63629-1326; 66267-919; 68071-2434; 58118-0127; 68071-4122; 68071-3013; 45865-530; 36000-297; 58657-675; 42291-219; 68071-2391; 63629-1724; 0143-9929; 70518-2045; 53002-2642; 63629-8982; 70934-068; 45865-979; 68788-7864; 69251-201; 50090-4314; 71335-0070; 70518-0464
Synonyms Ciprofloxacin | Ciprofloxacin Hydrochloride Anhydrous | Anhydrous, Ciprofloxacin Hydrochloride | Hydrochloride Anhydrous, Ciprofloxacin | Cipro | Ciprofloxacin Hydrochloride | Hydrochloride, Ciprofloxacin | Ciprofloxacin Monohydrochloride Monohydrate | Monohydrate, Ciprofloxacin Monohydrochloride | Monohydrochloride Monohydrate, Ciprofloxacin | Bay-09867 | Bay 09867 | Bay09867 | Ciprinol
Chemical Information
Molecular Formula C17H18FN3O3
CAS Registry Number 85721-33-1
SMILES C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Acute hepatic failureAlanine aminotransferase 1P24298Not Available3542945; 2686432; 15120718
Acute hepatic failureAspartate aminotransferase, mitochondrialP00505Not Available1591420; 7841570; 12086547
Acute hepatic failureAlanine aminotransferase 1P24298Not Available1591420; 7841570; 12086547
DeathDNA gyrase subunit AP48369Not Available15256030; 15380025; 16466897
HaematotoxicityAlanine aminotransferase 1P24298Not Available1591420; 7841570; 12086547
HaematotoxicityAlanine aminotransferase 1P24298Not Available3542945; 2686432; 15120718
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.000090%
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abortion spontaneous18.01.04.0010.005059%Not Available
Acidosis14.01.03.002--
Ageusia17.02.07.001; 07.14.03.003--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000090%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anosmia22.04.03.006; 17.04.04.001--
Anthrax11.02.22.001--Not Available
Anxiety19.06.02.0020.000134%
Apathy19.04.04.002--Not Available
Aphasia17.02.03.001; 19.21.01.001--
Application site pain12.07.01.004; 08.02.01.004--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.0010.000224%
Arthritis15.01.01.001--
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