Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azithromycin monohydrate
Drug ID BADD_D00205
Description Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. It is structurally related to erythromycin [A174169]. Azithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism. This differentiates azithromycin from other types of macrolides [A174175]. In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine]. The results were positive, all patients taking the combination were virologically cured within 6 days of treatment, however, larger studies are required.[A192546]
Indications and Usage For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal
Marketing Status Prescription; Discontinued
ATC Code J01FA10; S01AA26
DrugBank ID DB00207
KEGG ID D06390
MeSH ID D017963
PubChem ID 9897015
NDC Product Code 60687-271; 43063-715; 70860-100; 71205-427; 48792-7870; 65162-708; 68071-3136; 68083-199; 0904-6909; 68180-162; 68180-161; 65162-759; 54348-857; 0527-2395; 63323-398; 0904-6708; 68788-7654; 55154-8094; 60687-282; 71205-119; 48792-7869; 70232-0006; 66639-011; 61919-170; 70518-0803; 65162-758; 70860-125; 43063-713; 0527-2370; 46708-866; 61919-096; 70518-3094; 60687-314; 65372-1106; 53002-3221; 17478-307; 46708-865; 51672-4200; 65162-760; 43063-728; 70518-0736; 68071-3169; 68180-160
Synonyms Azithromycin | Azythromycin | Sumamed | Toraseptol | Vinzam | CP-62993 | CP 62993 | CP62993 | Zithromax | Azitrocin | Azadose | Ultreon | Zitromax | Azithromycin Dihydrate | Dihydrate, Azithromycin | Azithromycin Monohydrate | Monohydrate, Azithromycin | Goxal | Zentavion
Chemical Information
Molecular Formula C38H74N2O13
CAS Registry Number 117772-70-0
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Ageusia17.02.07.001; Available
Aggression19.05.01.001--Not Available
Anaphylactic reaction24.06.03.006;
Angioedema23.04.01.001; Available
Asthenia08.01.01.001--Not Available
Blood bilirubin13.03.01.040--Not Available
Blood creatinine13.13.01.020--Not Available
Burn dressing25.12.01.003--Not Available
Deafness04.02.01.001--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Erythema multiforme23.03.01.003;
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
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